Benzamide, 3-[5-chloro-4-[(2,4-difluorophenyl)methoxy]-6-oxo-1(6H)-pyrimidinyl]-N-[ (2R)-2,3-dihydroxypropyl]-4-methyl-

Base Information

Chemical Name:Benzamide, 3-[5-chloro-4-[(2,4-difluorophenyl)methoxy]-6-oxo-1(6H)-pyrimidinyl]-N-[ (2R)-2,3-dihydroxypropyl]-4-methyl-
CAS No.:773103-49-4
Molecular Formula:C₂₂H₂₀ClF₂N₃O₅
Molecular Weight:479.868
Hs Code.:

Synonyms:

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Chemical Property of Benzamide, 3-[5-chloro-4-[(2,4-difluorophenyl)methoxy]-6-oxo-1(6H)-pyrimidinyl]-N-[ (2R)-2,3-dihydroxypropyl]-4-methyl-

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Technology Process of Benzamide, 3-[5-chloro-4-[(2,4-difluorophenyl)methoxy]-6-oxo-1(6H)-pyrimidinyl]-N-[ (2R)-2,3-dihydroxypropyl]-4-methyl-

There total 9 articles about Benzamide, 3-[5-chloro-4-[(2,4-difluorophenyl)methoxy]-6-oxo-1(6H)-pyrimidinyl]-N-[ (2R)-2,3-dihydroxypropyl]-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₂N₂O₄S

: 773103-49-4
C₂₂H₂₀ClF₂N₃O₅

Guidance literature:: Multi-step reaction with 7 steps

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 20 °C

3: Raney Ni / N,N-dimethyl acetamide / 12 h / 80 °C

4: citric acid; sodium hydroxide / 1,4-dioxane / 1 h / 20 °C

5: dichloro-acetic acid; N-chloro-succinimide / 1,2-dichloro-ethane / 65 °C

6: 4-methyl-morpholine / N,N-dimethyl acetamide

With 4-methyl-morpholine; dichloro-acetic acid; N-chloro-succinimide; potassium carbonate; citric acid; sodium hydroxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.05.006

Reference yield:

: 773104-00-0
methyl 3-[(aminocarbonothioyl)amino]-4-methylbenzoate

: 773103-49-4
C₂₂H₂₀ClF₂N₃O₅

Guidance literature:: Multi-step reaction with 8 steps

1: sodium methylate

3: potassium carbonate / 1-methyl-pyrrolidin-2-one / 20 °C

4: Raney Ni / N,N-dimethyl acetamide / 12 h / 80 °C

5: citric acid; sodium hydroxide / 1,4-dioxane / 1 h / 20 °C

6: dichloro-acetic acid; N-chloro-succinimide / 1,2-dichloro-ethane / 65 °C

7: 4-methyl-morpholine / N,N-dimethyl acetamide

With 4-methyl-morpholine; dichloro-acetic acid; N-chloro-succinimide; sodium methylate; potassium carbonate; citric acid; sodium hydroxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.05.006

Reference yield:

: 773104-01-1
3-(4-hydroxy-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-yl)-4-methyl-benzoic acid methyl ester

: 773103-49-4
C₂₂H₂₀ClF₂N₃O₅

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 20 °C

2: Raney Ni / N,N-dimethyl acetamide / 12 h / 80 °C

3: citric acid; sodium hydroxide / 1,4-dioxane / 1 h / 20 °C

4: dichloro-acetic acid; N-chloro-succinimide / 1,2-dichloro-ethane / 65 °C

5: 4-methyl-morpholine / N,N-dimethyl acetamide

With 4-methyl-morpholine; dichloro-acetic acid; N-chloro-succinimide; potassium carbonate; citric acid; sodium hydroxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.05.006