L-Isoleucine, L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-

Base Information

Chemical Name:L-Isoleucine, L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-
CAS No.:77654-52-5
Molecular Formula:C₃₂H₄₆N₆O₇
Molecular Weight:626.753
Hs Code.:
DSSTox Substance ID:DTXSID40431394
Wikidata:Q82245252

Synonyms:L-Isoleucine, L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-;100900-41-2;[Des-tyr1]-beta-casomorphin;(2S,3S)-3-methyl-2-[[(2S)-1-[2-[[(2S)-1-[(2S)-3-phenyl-2-[[(2S)-pyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]pentanoic acid;77654-52-5;Pro-Phe-Pro-Gly-Pro-Ile;DTXSID40431394

Suppliers and Price of L-Isoleucine, L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of L-Isoleucine, L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-

Chemical Property:

XLogP3:-0.9
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:13
Exact Mass:626.34279783
Heavy Atom Count:45
Complexity:1100

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(C)C(C(=O)O)NC(=O)C1CCCN1C(=O)CNC(=O)C2CCCN2C(=O)C(CC3=CC=CC=C3)NC(=O)C4CCCN4
Isomeric SMILES:CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@@H]4CCCN4

Technology Process of L-Isoleucine, L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-

There total 15 articles about L-Isoleucine, L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85713-96-8
N-tert-butyloxycarbonyl-L-prolyl-L-phenylalanyl-L-prolylglycine

: 77654-52-5
L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-L-isoleucine

Guidance literature:

Reference yield:

: 16652-75-8
L-isoleucine benzyl ester tosylate

: 77654-52-5
L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-L-isoleucine

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / Et₃N / 1,2-dichloro-ethane

2: TFA

3: 75 percent / WSC / CH₂Cl₂

4: TFA

5: H₂ / Pd-C

With hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1246/cl.1989.679

Reference yield:

: 3392-10-7
tert-butoxycarbonyl-L-proline N-hydroxysuccinimide ester

: 77654-52-5
L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-L-isoleucine

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / Et₃N / 1,2-dichloro-ethane

2: TFA

3: 75 percent / WSC / CH₂Cl₂

4: TFA

5: H₂ / Pd-C

With hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1246/cl.1989.679