1-Piperazinecarboxylic acid, 4-[4-[3-[(2-fluorophenyl)methoxy]propoxy]phenyl]-3-[(2-naphthalenyloxy) methyl]-5-oxo-, 1,1-dimethylethyl ester, (3R)-

Base Information

• Chemical Name: 1-Piperazinecarboxylic acid, 4-[4-[3-[(2-fluorophenyl)methoxy]propoxy]phenyl]-3-[(2-naphthalenyloxy) methyl]-5-oxo-, 1,1-dimethylethyl ester, (3R)-
• CAS No.: 777934-62-0
• Molecular Formula: C36H39FN2O6
• Molecular Weight: 614.714
• Mol file: 777934-62-0.mol

Synonyms:

Chemical Property of 1-Piperazinecarboxylic acid, 4-[4-[3-[(2-fluorophenyl)methoxy]propoxy]phenyl]-3-[(2-naphthalenyloxy) methyl]-5-oxo-, 1,1-dimethylethyl ester, (3R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Piperazinecarboxylic acid, 4-[4-[3-[(2-fluorophenyl)methoxy]propoxy]phenyl]-3-[(2-naphthalenyloxy) methyl]-5-oxo-, 1,1-dimethylethyl ester, (3R)-

There total 1 articles about 1-Piperazinecarboxylic acid, 4-[4-[3-[(2-fluorophenyl)methoxy]propoxy]phenyl]-3-[(2-naphthalenyloxy) methyl]-5-oxo-, 1,1-dimethylethyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

o-fluorobenzyl bromide (446-48-0) + (3R)-4-(4-(3-hydroxypropoxy)phenyl)-3-(naphthalene-2-yloxymethyl)-5-oxopiperazine-1-carboxylic acid tert-butyl ester (777934-61-9) → (3R)-4-(4-[3-(2-fluorobenzyloxy)propoxy]phenyl)-3-(naphthalene-2-yloxymethyl)-5-oxopiperazine-1-carboxylic acid tert-butyl ester (777934-62-0)

Guidance literature:

With sodium hydride; 15-crown-5; In DMF (N,N-dimethyl-formamide); at 20 - 60 ℃; for 3h;

Reference yield: 59.7%

(3R)-4-(4-[3-(2-fluorobenzyloxy)propoxy]phenyl)-3-(naphthalene-2-yloxymethyl)-5-oxopiperazine-1-carboxylic acid tert-butyl ester (777934-62-0) → (6R)-1-(4-[3-(2-fluorobenzyloxy)propoxy]phenyl)-6-(naphthalene-2-yloxymethyl)piperazin-2-one

Guidance literature:

With acetyl chloride; In methanol; at 0 - 20 ℃; for 18h;

upstream raw materials:

o-fluorobenzyl bromide

(3R)-4-(4-(3-hydroxypropoxy)phenyl)-3-(naphthalene-2-yloxymethyl)-5-oxopiperazine-1-carboxylic acid tert-butyl ester