2'-deoxycytidylyl-(3'-5')-thymidine

Base Information

• Chemical Name: 2'-deoxycytidylyl-(3'-5')-thymidine
• CAS No.: 4829-64-5
• Molecular Formula: C19H26N5O11P
• Molecular Weight: 531.4104
• Mol file: 4829-64-5.mol

Synonyms:2'-deoxy-cytidylyl-(3'->5')-thymidine;Deoxycytidylylthymidin-monophosphat;d[CpT];Phosphoric acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester;dC-dT;d;Deoxycytidylthymidin;

Chemical Property of 2'-deoxycytidylyl-(3'-5')-thymidine

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 240.26000
• Density: 1.91g/cm³
• LogP: -1.30430

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-deoxycytidylyl-(3'-5')-thymidine

There total 20 articles about 2'-deoxycytidylyl-(3'-5')-thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite] (140613-57-6) → 2'-deoxycytidylyl-(3',5')-thymidine phosphate (4829-64-5)

Guidance literature:

Multistep reaction;

DOI:10.1021/ja048125h

Reference yield: 94.0%

5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite] (140613-57-6) → 2'-deoxycytidylyl-(3',5')-thymidine phosphate (4829-64-5)

Guidance literature:

Multistep reaction.;

DOI:10.1016/j.tetlet.2003.10.156

Reference yield:

dIPA(OMe)T> → d + 2'-deoxycytidylyl-(3',5')-thymidine phosphate (4829-64-5)

Guidance literature:

With ammonium hydroxide; In methanol; at 20 ℃; for 0.333333h;

DOI:10.1016/S0040-4039(00)73809-3

upstream raw materials:

C₅₃H₅₉ClN₅O₁₄PSi

Benzoic acid (2R,3S,5R)-2-[[(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(4-chloro-phenoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

3'-O-acetylthymidine

5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]