1-[(2S)-1-(4-Methylbenzene-1-sulfonyl)pyrrolidin-2-yl]propan-1-one

Base Information

Chemical Name:1-[(2S)-1-(4-Methylbenzene-1-sulfonyl)pyrrolidin-2-yl]propan-1-one
CAS No.:77815-25-9
Molecular Formula:C₁₄H₁₉NO₃S
Molecular Weight:281.376
Hs Code.:
DSSTox Substance ID:DTXSID80505482
Wikidata:Q82360658

Synonyms:77815-25-9;DTXSID80505482;1-[(2S)-1-(4-Methylbenzene-1-sulfonyl)pyrrolidin-2-yl]propan-1-one

Suppliers and Price of 1-[(2S)-1-(4-Methylbenzene-1-sulfonyl)pyrrolidin-2-yl]propan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-[(2S)-1-(4-Methylbenzene-1-sulfonyl)pyrrolidin-2-yl]propan-1-one

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:281.10856464
Heavy Atom Count:19
Complexity:419

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(=O)C1CCCN1S(=O)(=O)C2=CC=C(C=C2)C
Isomeric SMILES:CCC(=O)[C@@H]1CCCN1S(=O)(=O)C2=CC=C(C=C2)C

Technology Process of 1-[(2S)-1-(4-Methylbenzene-1-sulfonyl)pyrrolidin-2-yl]propan-1-one

There total 4 articles about 1-[(2S)-1-(4-Methylbenzene-1-sulfonyl)pyrrolidin-2-yl]propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 925-90-6
ethylmagnesium bromide

: 51077-01-1,110771-95-4
L-N-tosyl-proline

: 77815-25-9
(S)-(-)-<1-(4-toluensulphonyl)-1-azacyclopentan-2-yl>-1-propanone

Guidance literature:: With pivaloyl chloride; triethylamine; Yield given. Multistep reaction; 1.) THF, -35 deg C, 25 min, 2.) Et₂O, -78 deg C, 10 min;
DOI:10.1021/ja00401a031

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 77815-25-9
(S)-(-)-<1-(4-toluensulphonyl)-1-azacyclopentan-2-yl>-1-propanone

Guidance literature:: Multi-step reaction with 2 steps

2: 1.) Et₃N, Me₃CCOCl / 1.) THF, -35 deg C, 25 min, 2.) Et₂O, -78 deg C, 10 min

With pivaloyl chloride; triethylamine;
DOI:10.1021/ja00401a031

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 77815-25-9
(S)-(-)-<1-(4-toluensulphonyl)-1-azacyclopentan-2-yl>-1-propanone

Guidance literature:: Multi-step reaction with 2 steps

2: 1.) Et₃N, Me₃CCOCl / 1.) THF, -35 deg C, 25 min, 2.) Et₂O, -78 deg C, 10 min

With pivaloyl chloride; triethylamine;
DOI:10.1021/ja00401a031