1-[(Benzyloxy)carbonyl]-5-oxo-L-prolyl-L-valyl-L-prolinamide

Base Information

Chemical Name:1-[(Benzyloxy)carbonyl]-5-oxo-L-prolyl-L-valyl-L-prolinamide
CAS No.:78058-06-7
Molecular Formula:C23H30N4O6
Molecular Weight:458.514
Hs Code.:
DSSTox Substance ID:DTXSID00707047
Wikidata:Q82640683

Synonyms:78058-06-7;SCHEMBL11339140;DTXSID00707047;1-[(Benzyloxy)carbonyl]-5-oxo-L-prolyl-L-valyl-L-prolinamide

Suppliers and Price of 1-[(Benzyloxy)carbonyl]-5-oxo-L-prolyl-L-valyl-L-prolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-[(Benzyloxy)carbonyl]-5-oxo-L-prolyl-L-valyl-L-prolinamide

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:458.21653469
Heavy Atom Count:33
Complexity:779

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C(C(=O)N1CCCC1C(=O)N)NC(=O)C2CCC(=O)N2C(=O)OCC3=CC=CC=C3
Isomeric SMILES:CC(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N)NC(=O)[C@@H]2CCC(=O)N2C(=O)OCC3=CC=CC=C3

Technology Process of 1-[(Benzyloxy)carbonyl]-5-oxo-L-prolyl-L-valyl-L-prolinamide

There total 4 articles about 1-[(Benzyloxy)carbonyl]-5-oxo-L-prolyl-L-valyl-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78058-05-6
H-Val-Pro-NH₂*HCl

: 78148-14-8
benzyloxycarbonylpyroglutamic acid pentafluorophenyl ester

: 78058-06-7
Z-pGlu-Val-Pro-NH₂

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 0.166667h; Yield given;
DOI:10.1021/jm00372a006

Reference yield:

: 107897-23-4
N-(t-butoxycarbonyl)-L-valyl-L-prolinamide

: 78058-06-7
Z-pGlu-Val-Pro-NH₂

Guidance literature:: Multi-step reaction with 2 steps

1: 2 N HCl / ethyl acetate / 1 h / Ambient temperature

2: Et₃N / dimethylformamide / 0.17 h / 0 - 5 °C

With hydrogenchloride; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00372a006

Reference yield:

: 50903-49-6
2(S)-((tert-butoxycarbonyl)amino)-3-methyl-butyric acid 2,3,4,5,6-pentafluorophenyl ester

: 78058-06-7
Z-pGlu-Val-Pro-NH₂

Guidance literature:: Multi-step reaction with 3 steps

1: DMFA / 1 h / Ambient temperature

2: 2 N HCl / ethyl acetate / 1 h / Ambient temperature

3: Et₃N / dimethylformamide / 0.17 h / 0 - 5 °C

With hydrogenchloride; triethylamine; N,N-dimethyl-formamide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00372a006