Acetamide, N-[(2-iodophenyl)methyl]-

Base Information

Chemical Name:Acetamide, N-[(2-iodophenyl)methyl]-
CAS No.:78108-43-7
Molecular Formula:C9H10INO
Molecular Weight:275.089
Hs Code.:
DSSTox Substance ID:DTXSID00385006
Wikidata:Q82177530

Synonyms:Acetamide, N-[(2-iodophenyl)methyl]-;78108-43-7;N-(2-iodobenzyl)acetamide;DTXSID00385006

Suppliers and Price of Acetamide, N-[(2-iodophenyl)methyl]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetamide, N-[(2-iodophenyl)methyl]-

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:274.98071
Heavy Atom Count:12
Complexity:161

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)NCC1=CC=CC=C1I

Technology Process of Acetamide, N-[(2-iodophenyl)methyl]-

There total 6 articles about Acetamide, N-[(2-iodophenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 39959-51-8
2-iodobenzylamine

: 108-24-7
acetic anhydride

: 78108-43-7
diethyl 2-(2-iodophenethyl)malonate

Guidance literature:: With hydrogenchloride; sodium hydroxide;
DOI:10.1021/jo00330a021

Reference yield:

: 5159-41-1
2-iodobenzyl alcohol

: 78108-43-7
diethyl 2-(2-iodophenethyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / (PhO)2P(O)N₃; DBU / toluene / 1 h / 20 °C

2.1: PPh₃ / tetrahydrofuran / 16 h / 20 °C

2.2: aq. NH₃ / 3 h

2.3: aq. NaOH / 1 h

3.1: pyridine / 2 h / 20 °C

With pyridine; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(01)00991-7

Reference yield:

: 405198-82-5
1-(azidomethyl)-2-iodobenzene

: 78108-43-7
diethyl 2-(2-iodophenethyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: PPh₃ / tetrahydrofuran / 16 h / 20 °C

1.2: aq. NH₃ / 3 h

1.3: aq. NaOH / 1 h

2.1: pyridine / 2 h / 20 °C

With pyridine; triphenylphosphine; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)00991-7