ethyl N-[5-amino-3-(4-chlorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate

Base Information

Chemical Name:ethyl N-[5-amino-3-(4-chlorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate
CAS No.:82585-96-4
Molecular Formula:C16H16ClN5O2
Molecular Weight:345.788
Hs Code.:
NSC Number:281295
DSSTox Substance ID:DTXSID001002803
Wikidata:Q82997083
ChEMBL ID:CHEMBL9635

Synonyms:82585-96-4;NSC281295;CHEMBL9635;ethyl N-[5-amino-3-(4-chlorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate;DTXSID001002803;NSC 281295;NSC-281295;Ethyl (5-amino-3-(4-chlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)carbamate;N-[5-Amino-3-(4-chlorophenyl)(1,2-dihydropyridino[5,4-b]pyrazin-7-yl)]ethoxycarboxamide;Carbamic acid, (5-amino-3-(4-chlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester;Ethyl hydrogen [5-amino-3-(4-chlorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbonimidate

Suppliers and Price of ethyl N-[5-amino-3-(4-chlorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of ethyl N-[5-amino-3-(4-chlorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate

Chemical Property:

Vapor Pressure:3.77E-10mmHg at 25°C
Boiling Point:500.5°Cat760mmHg
Flash Point:256.5°C
Density:1.48g/cm³
XLogP3:2.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:345.0992525
Heavy Atom Count:24
Complexity:481

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)NC1=NC(=C2C(=C1)NCC(=N2)C3=CC=C(C=C3)Cl)N

Technology Process of ethyl N-[5-amino-3-(4-chlorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate

There total 3 articles about ethyl N-[5-amino-3-(4-chlorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 82585-78-2
{6-Amino-4-[2-(4-chloro-phenyl)-2-oxo-ethylamino]-5-nitro-pyridin-2-yl}-carbamic acid ethyl ester

: 82585-96-4
[5-Amino-3-(4-chloro-phenyl)-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl]-carbamic acid ethyl ester

Guidance literature:: With hydrogen; nickel; In 1,4-dioxane; ethanol; for 19h; under 760 Torr; Heating;
DOI:10.1021/jm00351a008

Reference yield:

: 2-Amino-1-(4-chloro-phenyl)-ethanone oxime

: 82585-96-4
[5-Amino-3-(4-chloro-phenyl)-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl]-carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / Et₃N / ethanol / 3 h / 75 °C

2: 59 percent / 1N aq. HCl / dioxane / 18 h / 60 °C

3: 77 percent / H₂ / Raney nickel / ethanol; dioxane / 19 h / 760 Torr / Heating

With hydrogenchloride; hydrogen; triethylamine; nickel; In 1,4-dioxane; ethanol;
DOI:10.1021/jm00351a008

Reference yield:

: 82585-64-6
(6-Amino-4-{2-(4-chloro-phenyl)-2-[(Z)-hydroxyimino]-ethylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester

: 82585-96-4
[5-Amino-3-(4-chloro-phenyl)-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl]-carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / 1N aq. HCl / dioxane / 18 h / 60 °C

2: 77 percent / H₂ / Raney nickel / ethanol; dioxane / 19 h / 760 Torr / Heating

With hydrogenchloride; hydrogen; nickel; In 1,4-dioxane; ethanol;
DOI:10.1021/jm00351a008