Trityl Valsartan

Base Information

• Chemical Name: Trityl Valsartan
• CAS No.: 783369-52-8
• Molecular Formula: C43H43N5O3
• Molecular Weight: 677.846
• Mol file: 783369-52-8.mol

Synonyms:N-pentanoyl-N-[{2''-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1''-biphenyl-4-yl}methyl]-L-valinate;Trityl Valsartan;N-pentanoyl-N-[{2''-[1-(triphenylmethyl)-1H-tetrazol-5-yl]-1,1''-biphenyl-4-yl}methyl]-L-valine;

Chemical Property of Trityl Valsartan

Chemical Property:

• PSA: 101.21000
• LogP: 8.47530

Purity/Quality:

98% ^*data from raw suppliers

TritylValsartan ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Trityl Valsartan

There total 4 articles about Trityl Valsartan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeroyl-(L)-valine benzyl ester (137864-44-9) → N-pentanoyl-N-(4-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)phenyl)methyl-L-valine (783369-52-8)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In ethyl acetate; at 20 ℃; for 3h;

Reference yield:

N-(4-(2-(1-trityl-1H-tetrazole-5-yl)phenyl)phenyl)methyl-L-valine + n-valeryl chloride (638-29-9) → N-pentanoyl-N-(4-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)phenyl)methyl-L-valine (783369-52-8)

Guidance literature:

N-(4-(2-(1-trityl-1H-tetrazole-5-yl)phenyl)phenyl)methyl-L-valine; With sodium hydrogencarbonate; In toluene; for 0.5h;

n-valeryl chloride; In toluene; at 5 - 20 ℃; for 30h;

Reference yield:

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole (124750-51-2) → N-pentanoyl-N-(4-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)phenyl)methyl-L-valine (783369-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 0.5 h

1.2: 8 h / Reflux

2.1: sodium hydrogencarbonate / toluene / 0.5 h

2.2: 30 h / 5 - 20 °C

With sodium hydrogencarbonate; potassium carbonate; In toluene; acetonitrile;

upstream raw materials:

N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeroyl-(L)-valine benzyl ester

n-valeryl chloride

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Downstream raw materials:

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Refernces

• 1、 -. "For renin-angiotensin-aldosterone system dual inhibitor compounds". Paragraph 0041; 0044; 0045. . Retrieved 2016/12/01.
• 2、 -. "INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF AN ANGIOTENSIN II RECEPTOR ANTAGONIST". Page/Page column 27-28. . Retrieved 2008/06/13.