7a-benzylhexahydro-1H-pyrrolizine

Base Information

Chemical Name:7a-benzylhexahydro-1H-pyrrolizine
CAS No.:78449-74-8
Molecular Formula:C₁₄H₁₉N
Molecular Weight:201.312
Hs Code.:
DSSTox Substance ID:DTXSID70507031
Wikidata:Q82363042

Synonyms:7a-benzylhexahydro-1H-pyrrolizine;78449-74-8;8-benzyl-1,2,3,5,6,7-hexahydropyrrolizine;DTXSID70507031

Suppliers and Price of 7a-benzylhexahydro-1H-pyrrolizine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7a-benzylhexahydro-1H-pyrrolizine

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:201.151749610
Heavy Atom Count:15
Complexity:207

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2(CCCN2C1)CC3=CC=CC=C3

Technology Process of 7a-benzylhexahydro-1H-pyrrolizine

There total 2 articles about 7a-benzylhexahydro-1H-pyrrolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1589-82-8
phenylmagnesium bromide

: 1-azoniabicyclo[3.3.0]oct-1⁽⁵⁾-ene perchlorate

: 78449-74-8
7a-benzyl-hexahydro-1H-pyrrolizine

Guidance literature:: In diethyl ether; for 20h; Heating; 2.) 20percent aqueous NaOH;
DOI:10.1002/jhet.5570240152

Reference yield:

: 1-azoniabicyclo[3.3.0]oct-1⁽⁵⁾-ene perchlorate

: 37782-11-9
benzylmagnesium iodidide

: 78449-74-8
7a-benzyl-hexahydro-1H-pyrrolizine

Guidance literature:: In diethyl ether; for 3h; Ambient temperature;

Reference yield:

: 78449-74-8
7a-benzyl-hexahydro-1H-pyrrolizine

: 105073-20-9
5-benzyl-1-methylperhydroazocine

Guidance literature:: Multi-step reaction with 3 steps

1: methanol

2: 1.) IRA-410, 2.) ethanol / 1.) methanol, 2.) reflux, 2-5 h

3: 48.5 percent / H₂ / PtO₂ / acetic acid / 0.67 h

With ethanol; IRA-410; hydrogen; platinum(IV) oxide; In methanol; acetic acid;