Technology Process of 2-Piperidinecarboxylic acid, 6-oxo-, pentafluorophenyl ester, (S)-
There total 7 articles about 2-Piperidinecarboxylic acid, 6-oxo-, pentafluorophenyl ester, (S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dicyclohexyl-carbodiimide;
In
ethyl acetate;
at 0 - 5 ℃;
for 3h;
DOI:10.1021/jm00159a015
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 84 percent / aq. NaOH, aq. Na2CO3 / 3 h / 0 - 5 °C
2: 82 percent / aq. NaOH, KMnO4 / 2 h / 5 - 10 °C
3: 83 percent / H2, 60percent aq. AcOH / 10percent Pd/C / 2 h
4: 68 percent / 20percent aq. AcOH / 3 h / Heating
5: 92 percent / dicyclohexylcarbodiimide / ethyl acetate / 3 h / 0 - 5 °C
With
sodium hydroxide; potassium permanganate; hydrogen; sodium carbonate; acetic acid; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
ethyl acetate;
DOI:10.1021/jm00159a015
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 83 percent / H2, 60percent aq. AcOH / 10percent Pd/C / 2 h
2: 68 percent / 20percent aq. AcOH / 3 h / Heating
3: 92 percent / dicyclohexylcarbodiimide / ethyl acetate / 3 h / 0 - 5 °C
With
hydrogen; acetic acid; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
ethyl acetate;
DOI:10.1021/jm00159a015
