N-(2-Bromo-5-methoxyphenyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-(2-Bromo-5-methoxyphenyl)-2,2,2-trifluoroacetamide
CAS No.:78839-76-6
Molecular Formula:C9H7BrF3NO2
Molecular Weight:298.059
Hs Code.:
DSSTox Substance ID:DTXSID50507913
Wikidata:Q82364482

Synonyms:N-(2-Bromo-5-methoxyphenyl)-2,2,2-trifluoroacetamide;78839-76-6;DTXSID50507913;AKOS012680525

Suppliers and Price of N-(2-Bromo-5-methoxyphenyl)-2,2,2-trifluoroacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-(2-Bromo-5-methoxyphenyl)-2,2,2-trifluoroacetamide

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:296.96123
Heavy Atom Count:16
Complexity:260

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)Br)NC(=O)C(F)(F)F

Technology Process of N-(2-Bromo-5-methoxyphenyl)-2,2,2-trifluoroacetamide

There total 1 articles about N-(2-Bromo-5-methoxyphenyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 59557-92-5
2-bromo-5-methoxyaniline

: 407-25-0
trifluoroacetic anhydride

: 78839-76-6
N-(2-bromo-5-methoxyphenyl)-2,2,2-trifluoroacetamide

Guidance literature:: With sodium carbonate; In diethyl ether; for 24h; Ambient temperature;
DOI:10.1016/S0040-4020(01)88618-X

Reference yield: 41.0%

: 78839-76-6
N-(2-bromo-5-methoxyphenyl)-2,2,2-trifluoroacetamide

: 52898-78-9
3-(2,6-dihydroxyphenyl)-2-methylquinazolin-4(3H)-one

: 2,2,2-trifluoro-N-(2-(3-hydroxy-2-(2-methyl-4-oxoquinazolin-3(4H)-yl)phenoxy)-5-methoxyphenyl)acetamide

Guidance literature:: With copper(l) iodide; lithium (S)-1-((R)-3-((bis(dimethylamino)methylene)ammonio)-3-carboxylatopropanoyl)-2-methylpyrrolidine-2-carboxylate; caesium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 48h; enantioselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.orglett.1c04266

Reference yield:

: 78839-76-6
N-(2-bromo-5-methoxyphenyl)-2,2,2-trifluoroacetamide

: 3382-43-2
7-methoxy-2,3,4,9-tetrahydro-1H-carbazole

: 14818-55-4
N-(3-methoxyphenyl)-2,2,2-trifluoroacetamide

Guidance literature:: With methyllithium; tert.-butyl lithium; Yield given. Multistep reaction. Yields of byproduct given;
DOI:10.1016/S0040-4020(01)88618-X