methyl 3-bromo-4-(bromomethyl)benzoate

Base Information

• Chemical Name: methyl 3-bromo-4-(bromomethyl)benzoate
• CAS No.: 78946-25-5
• Molecular Formula: C9H8Br2O2
• Molecular Weight: 307.969
• Mol file: 78946-25-5.mol

Synonyms:3-bromo-4-bromomethylbenzoic acid methyl ester;Methyl 3,α-Dibromo-p-toluate;Methyl 3-bromo-4-(bromomethyl)benzoate;3-bromo-4-bromomethyl-benzoic acid methyl ester;

Chemical Property of methyl 3-bromo-4-(bromomethyl)benzoate

Chemical Property:

• PSA: 26.30000
• LogP: 3.13060

Purity/Quality:

99%min ^*data from raw suppliers

3-Bromo-4-bromomethyl-benzoicacidmethylester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-bromo-4-(bromomethyl)benzoate

There total 4 articles about methyl 3-bromo-4-(bromomethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 3-bromo-4-methylbenzoate (104901-43-1) → 3-bromo-4-(bromomethyl)benzoic acid methyl ester (78946-25-5)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In benzene; for 6h; Irradiation;

DOI:10.1016/j.bmc.2008.05.062

Reference yield: 37.0%

methyl 3-bromo-4-methylbenzoate (104901-43-1) → methyl 3-bromo-4-(dibromomethyl)benzoate (1001200-40-3) + 3-bromo-4-(bromomethyl)benzoic acid methyl ester (78946-25-5)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 82 ℃; for 16h; Reagent/catalyst; Temperature; Concentration;

Reference yield:

3-bromo-4-methylbenzoic acid (7697-26-9) → 3-bromo-4-(bromomethyl)benzoic acid methyl ester (78946-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / H₂SO₄ / 10 h / 60 °C

2: 77 percent / NBS; benzoyl peroxide / CCl₄ / 10 h / 80 °C

With N-Bromosuccinimide; sulfuric acid; dibenzoyl peroxide; In tetrachloromethane;

DOI:10.1021/ja028249z

upstream raw materials:

methyl 3-bromo-4-methylbenzoate

3-bromo-4-methylbenzoic acid

Downstream raw materials:

3-Bromo-4-(2-phenyl-2-phenylamino-ethyl)-benzoic acid methyl ester

3-Bromo-4-(2-butyl-benzoimidazol-1-ylmethyl)-benzoic acid

methyl 3-Bromo-4-(1-tetrazolylmethyl)benzoate

methyl 4-(azidomethyl)-3-bromobenzoate

Refernces

• 1、 Eleya, Nadi,Li, Shuo,Staubitz, Anne. "Cross-coupling strategy for the synthesis of diazocines". supporting information. p. 1624 - 1627. Retrieved 2020/03/13.
• 2、 -. "GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES". Page/Page column 151; 152; 153. . Retrieved 2019/05/30.