Boc-L-aspartic acid ss-benzyl ester Merrifield resin

Base Information

Chemical Name:Boc-L-aspartic acid ss-benzyl ester Merrifield resin
CAS No.:79069-52-6
Molecular Formula:C16H21NO5
Molecular Weight:307.346
Hs Code.:
DSSTox Substance ID:DTXSID801148891
Nikkaji Number:J1.238.818G

Synonyms:SCHEMBL1261930;DTXSID801148891;MFCD00801164;79069-52-6;Boc-L-Asp(Bzl)-PAM resin (100-200 mesh);Boc-L-aspartic acid ss-benzyl ester Merrifield resin;Phenylmethyl (3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-oxobutanoate;Boc-L-aspartic acid b-benzyl ester 4-oxymethylphenylacetamidomethyl resin 100-200mesh 0.25-1.0 meq/g

Suppliers and Price of Boc-L-aspartic acid ss-benzyl ester Merrifield resin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Boc-L-aspartic acid ss-benzyl ester Merrifield resin

Chemical Property:

Boiling Point:451.3±45.0 °C(Predicted)
PSA：81.70000
Density:1.147±0.06 g/cm3(Predicted)
LogP:2.60300
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:307.14197277
Heavy Atom Count:22
Complexity:383

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC(=O)OCC1=CC=CC=C1)C=O
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H](CC(=O)OCC1=CC=CC=C1)C=O

Technology Process of Boc-L-aspartic acid ss-benzyl ester Merrifield resin

There total 5 articles about Boc-L-aspartic acid ss-benzyl ester Merrifield resin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 79069-16-2
benzyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoate

: 79069-52-6
N-Boc-L-aspartic aldehyde β-benzyl ester

Guidance literature:: With dipyridinium dichromate; In dichloromethane; Ambient temperature;
DOI:10.1021/jo00336a039

Reference yield: 72.0%

: 2-tert-butoxycarbonylamino-succinic acid 4-benzyl ester 4-(4,6-dimethoxy-[1,3,5]triazin-2-yl) ester

: 79069-52-6
N-Boc-L-aspartic aldehyde β-benzyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; at 20 ℃; for 3h;
DOI:10.1021/jo991112f

Reference yield:

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 79069-52-6
N-Boc-L-aspartic aldehyde β-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: iBuOCOCl; NMM / tetrahydrofuran / -10 °C

1.2: aq. NaBH₄ / tetrahydrofuran

2.1: Dess-Martin periodinane / CH₂Cl₂

With 4-methyl-morpholine; Dess-Martin periodane; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.12.056