methyl (2alpha)-ibogamine-18-carboxylate hydrochloride (1:1)

Base Information

Chemical Name:methyl (2alpha)-ibogamine-18-carboxylate hydrochloride (1:1)
CAS No.:28888-46-2
Molecular Formula:C₂₁H₂₆N₂O₂*ClH
Molecular Weight:374.911
Hs Code.:

Synonyms:Coronaridine,monohydrochloride, (?à)- (8CI); Ibogamine-18-carboxylic acid, methyl ester, monohydrochloride, (?à)- (9CI);6,9-Methano-5H-pyrido[1',2':1,2]azepino[4,5-b]indole, ibogamine-18-carboxylicacid deriv.; (?à)-Coronaridinehydrochloride

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Chemical Property of methyl (2alpha)-ibogamine-18-carboxylate hydrochloride (1:1)

Chemical Property:

Vapor Pressure:1.12E-09mmHg at 25°C
Boiling Point:488.1°Cat760mmHg
Flash Point:249°C
Density:g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of methyl (2alpha)-ibogamine-18-carboxylate hydrochloride (1:1)

There total 5 articles about methyl (2alpha)-ibogamine-18-carboxylate hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2468-21-5
catharinthine

: 28888-46-2,4503-12-2,7237-52-7
(+)-coronaridine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; platinum(IV) oxide / methanol / 0.08 h / 760.05 Torr / Inert atmosphere

2: [Ir(C₆H₂F₂-C₅H₃NCF₃)₂(4,4′-di-tert-butyl-2,2′-dipyridyl)]⁺ / methanol / 50 °C / Inert atmosphere; Flow reactor; UV-irradiation

3: trifluoroacetic acid / toluene / 3 h / 120 °C / Inert atmosphere

4: hydrogenchloride / diethyl ether / Inert atmosphere

With hydrogenchloride; platinum(IV) oxide; [Ir(C₆H₂F₂-C₅H₃NCF₃)₂(4,4′-di-tert-butyl-2,2′-dipyridyl)]⁺; hydrogen; trifluoroacetic acid; In methanol; diethyl ether; toluene;
DOI:10.1021/ja506170g

Reference yield:

: 136118-90-6
methyl 4-cyano-5-ethyl-1,4,7,8,9,10-hexahydro-2H-3,7-methanoazacycloundecino<5,4-b>indole-9-carboxylate

: 28888-46-2,4503-12-2,7237-52-7
(+)-coronaridine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 0.42 h / Inert atmosphere

2: trifluoroacetic acid / toluene / 3 h / 120 °C / Inert atmosphere

3: hydrogenchloride / diethyl ether / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In methanol; diethyl ether; toluene;
DOI:10.1021/ja506170g

Reference yield:

: 38542-83-5
(+)-dihydrocatharanthine

: 28888-46-2,4503-12-2,7237-52-7
(+)-coronaridine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: [Ir(C₆H₂F₂-C₅H₃NCF₃)₂(4,4′-di-tert-butyl-2,2′-dipyridyl)]⁺ / methanol / 50 °C / Inert atmosphere; Flow reactor; UV-irradiation

2: trifluoroacetic acid / toluene / 3 h / 120 °C / Inert atmosphere

3: hydrogenchloride / diethyl ether / Inert atmosphere

With hydrogenchloride; [Ir(C₆H₂F₂-C₅H₃NCF₃)₂(4,4′-di-tert-butyl-2,2′-dipyridyl)]⁺; trifluoroacetic acid; In methanol; diethyl ether; toluene;
DOI:10.1021/ja506170g