1,8-Diazaspiro[4.5]decan-4-one, 1-phenyl-

Base Information

Chemical Name:1,8-Diazaspiro[4.5]decan-4-one, 1-phenyl-
CAS No.:79139-50-7
Molecular Formula:C14H18N2O
Molecular Weight:230.31
Hs Code.:

Synonyms:1-phenyl-1,8-diaza-spiro[4.5]decan-4-one;1-phenyl-1,8-diazaspiro[4,5]decan-4-one;

Suppliers and Price of 1,8-Diazaspiro[4.5]decan-4-one, 1-phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1,8-Diazaspiro[4.5]decan-4-one, 1-phenyl-

Chemical Property:

Melting Point:100 °C
PSA：32.34000
LogP:1.98180

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 1,8-Diazaspiro[4.5]decan-4-one, 1-phenyl-

There total 10 articles about 1,8-Diazaspiro[4.5]decan-4-one, 1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 79139-48-3
8-benzyl-1-phenyl-1,8-diazaspiro<4,5>decanone-4

: 79139-50-7
1-phenyl-1,8-diazaspiro<4,5>decan-4-one

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In water; isopropyl alcohol; at 40 ℃;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 79139-50-7
1-phenyl-1,8-diazaspiro<4,5>decan-4-one

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / H₂O; acetic acid / 24 h / 25 °C

2: 1.) concentrated sulfuric acid / 1.) 70 deg C; 2.) hexamethylphosphoric triamide, 20 deg C, 24 h

3: 90 percent / 5 h / Heating

4: 45 percent / sodium hydride, ethanol / toluene / 24 h / Heating

5: 80 percent / diethyl ether / 6 h

6: 1.) 70percent Redal; 2.) 4 N hydrochloric acid / 1.) benzene, reflux, 3 h 2.) water, 50 deg C, 1 h

7: 85 percent / hydrogen, hydrochlorid acid / 10percent palladium on carbon / propan-2-ol; H₂O / 40 °C

With hydrogenchloride; ethanol; sulfuric acid; hydrogen; sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium on activated charcoal; In diethyl ether; water; acetic acid; isopropyl alcohol; toluene;

Reference yield:

: 968-86-5
1-benzyl-4-(phenylamino)piperidine-4-carbonitrile

: 79139-50-7
1-phenyl-1,8-diazaspiro<4,5>decan-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) concentrated sulfuric acid / 1.) 70 deg C; 2.) hexamethylphosphoric triamide, 20 deg C, 24 h

2: 90 percent / 5 h / Heating

3: 45 percent / sodium hydride, ethanol / toluene / 24 h / Heating

4: 80 percent / diethyl ether / 6 h

5: 1.) 70percent Redal; 2.) 4 N hydrochloric acid / 1.) benzene, reflux, 3 h 2.) water, 50 deg C, 1 h

6: 85 percent / hydrogen, hydrochlorid acid / 10percent palladium on carbon / propan-2-ol; H₂O / 40 °C

With hydrogenchloride; ethanol; sulfuric acid; hydrogen; sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium on activated charcoal; In diethyl ether; water; isopropyl alcohol; toluene;