Cyclohexanamine, 4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]-, trans-

Base Information

Chemical Name:Cyclohexanamine, 4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]-, trans-
CAS No.:791778-53-5
Molecular Formula:C₁₈H₂₇Cl₂N₃
Molecular Weight:356.338
Hs Code.:

Synonyms:

Suppliers and Price of Cyclohexanamine, 4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]-, trans-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
trans-4-[2-[4-(2,3-Dichlorophenyl)piperazin-1-yl]ethyl]cyclohexanamine
10mg
$ 165.00

American Custom Chemicals Corporation
TRANS-4-[2-[4-(2,3-DICHLOROPHENYL)PIPERAZIN-1-YL]ETHYL]CYCLOHEXANAMINE 95.00%
5MG
$ 451.22

Total 12 raw suppliers

Chemical Property of Cyclohexanamine, 4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]-, trans-

Chemical Property:

PSA：32.50000
LogP:4.72620

Purity/Quality:

99%, ^*data from raw suppliers

trans-4-[2-[4-(2,3-Dichlorophenyl)piperazin-1-yl]ethyl]cyclohexanamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses trans-4-[2-[4-(2,3-Dichlorophenyl)piperazin-1-yl]ethyl]cyclohexanamine, is an impurity of Cariprazine (C183490), an orally active D2/D3 dopamine receptor antagonist (1,2,3). Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression.

Technology Process of Cyclohexanamine, 4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]-, trans-

There total 48 articles about Cyclohexanamine, 4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 506427-91-4
trans N-tert-butoxycarbonyl-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]ethyl}-cyclohexylamine

: 791778-53-5
trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexane-1-amine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jm401318w

Reference yield: 87.0%

: 506427-91-4
trans N-tert-butoxycarbonyl-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexylamine

: 791778-53-5
trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexylamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 12h;

Reference yield: 84.5%

: 4-[2-[4-(2,3-dichlorophenyl)piperazine-1-yl]ethyl]cyclohexanone

: 791778-53-5
trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexane-1-amine

Guidance literature:: 4-[2-[4-(2,3-dichlorophenyl)piperazine-1-yl]ethyl]cyclohexanone; With benzylamine; In methanol; at 20 ℃; Molecular sieve;

With palladium 10% on activated carbon; hydrogen; In methanol; at 35 - 40 ℃; under 1520.1 Torr; Reagent/catalyst;