L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-phenylalanyl-

Base Information

Chemical Name:L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-phenylalanyl-
CAS No.:79259-44-2
Molecular Formula:C28H38N4O5
Molecular Weight:510.634
Hs Code.:
DSSTox Substance ID:DTXSID40453258
Nikkaji Number:J861.690F
Wikidata:Q82274365

Synonyms:79259-44-2;L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-phenylalanyl-;DTXSID40453258

Suppliers and Price of L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-phenylalanyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-phenylalanyl-

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:14
Exact Mass:510.28422033
Heavy Atom Count:37
Complexity:745

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(C(=O)N)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(C(C)C)NC(=O)OCC2=CC=CC=C2
Isomeric SMILES:CC(C)C[C@@H](C(=O)N)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](C(C)C)NC(=O)OCC2=CC=CC=C2

Technology Process of L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-phenylalanyl-

There total 4 articles about L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-phenylalanyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 687-51-4,13079-20-4,13366-40-0,15893-47-7
H-L-Leu-NH₂

: 4817-95-2
N-(benzyloxycarbonyl)-L-valyl-L-phenylalanine methyl ester

: 79259-44-2
N-cbz-L-Val-L-Phe-L-Leu-NH₂

Guidance literature:: With subtilisin-CLEC; In acetonitrile; at 40 ℃; for 40h;
DOI:10.1021/jo9618334

Reference yield: 52.0%

: 4817-95-2
N-(benzyloxycarbonyl)-L-valyl-L-phenylalanine methyl ester

: 10466-61-2
(2S)-amino-4-methylpentanamide hydrochloride

: 79259-44-2
N-cbz-L-Val-L-Phe-L-Leu-NH₂

Guidance literature:: In tetrachloromethane; for 1.5h; Ambient temperature; silica-bound α-chimotripsin;
DOI:10.1007/BF00901826

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 79259-44-2
N-cbz-L-Val-L-Phe-L-Leu-NH₂

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / N-ethyl morpholine, isobutyl chloroformate / ethyl acetate / 1.) 1 h, -30 deg C, 2.) 1 h, room temperature

2: 52 percent / CCl4; various solvent(s) / 1.5 h / Ambient temperature; silica-bound α-chimotripsin

With N-ethylmorpholine;; isobutyl chloroformate; In tetrachloromethane; ethyl acetate;
DOI:10.1007/BF00901826