Technology Process of 1,3-Benzenedicarboxylic acid,
5-[[4-([2,2'-bipyridin]-4-ylethynyl)phenyl]ethynyl]-, dimethyl ester
There total 2 articles about 1,3-Benzenedicarboxylic acid,
5-[[4-([2,2'-bipyridin]-4-ylethynyl)phenyl]ethynyl]-, dimethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
dimethyl 5-((4-ethynylphenyl)ethynyl)isophthalate;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
With
9-methoxy-9-BBN;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 2h;
4-bromo-2,2'-bipyridyl;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; hexane;
Heating;
DOI:10.1021/jp047454t
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 74 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 20 °C
2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 9-methoxy-9-borabicyclo[3.3.1]nonane / tetrahydrofuran; hexane / 2 h / -78 °C
2.3: 70 percent / Pd(PPh3)4 / tetrahydrofuran; hexane / Heating
With
tetrabutyl ammonium fluoride; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane;
DOI:10.1021/jp047454t
- Guidance literature:
-
In
tetrahydrofuran; ethanol;
soln. of org. ligand in THF added to ethanol, deaerated by bubbling N2 for 10 min, Ru(bpy)2Cl2*2H2O added, mixt. refluxed overnight under N2, cooled to room temp., filtered, pptd. by aq. NaPF6; washing (water), HRMS, elem. anal.;
DOI:10.1021/jp047454t
