AF-DX-250

Base Information

• Chemical Name: AF-DX-250
• CAS No.: 121029-35-4
• Molecular Formula: C₂₄H₃₁N₅O₂
• Molecular Weight: 421.542
• Mol file: 121029-35-4.mol

Synonyms:6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one,11-[[2-[(diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-, (+)- (9CI);AF-DX 250

Chemical Property of AF-DX-250

Chemical Property:

• PSA: 74.23000
• LogP: 3.21440

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AF-DX-250

There total 7 articles about AF-DX-250 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one (28797-48-0) + D,L-2-[(diethylamino)methyl]piperidine (100158-61-0,64168-09-8) → Otenzepad (102394-31-0,121029-35-4,122467-13-4,100158-38-1)

Guidance literature:

With sodium carbonate; In acetonitrile; for 5h; Heating;

DOI:10.1021/jm00128a008

Reference yield: 51.0%

11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one (28797-48-0) + (-)-2-<(diethylamino)methyl>piperidine (120990-93-4,64168-09-8) → (+)-11-<<2-<(diethylamino)methyl>-1-piperidinyl>acetyl>-5,11-dihydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one (121029-35-4,100158-38-1)

Guidance literature:

With sodium carbonate; In acetonitrile; for 5h; Heating;

DOI:10.1021/jm00128a008

Reference yield:

2-[(diethylamino)methyl]piperidine dihydrochloride (1219964-56-3) + 11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one (28797-48-0) → Otenzepad (102394-31-0,121029-35-4,122467-13-4,100158-38-1)

Guidance literature:

With sodium carbonate; In propan-1-ol; water; pyrographite; acetonitrile;

upstream raw materials:

11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

D,L-2-[(diethylamino)methyl]piperidine

5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

2-[(diethylamino)methyl]piperidine dihydrochloride

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