Benzenemethanol, 3-iodo-a-methyl-

Base Information

• Chemical Name: Benzenemethanol, 3-iodo-a-methyl-
• CAS No.: 79917-56-9
• Molecular Formula: C8H9IO
• Molecular Weight: 248.063
• Mol file: 79917-56-9.mol

Synonyms:

Chemical Property of Benzenemethanol, 3-iodo-a-methyl-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenemethanol, 3-iodo-a-methyl-

There total 4 articles about Benzenemethanol, 3-iodo-a-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3'-iodoacetophenone (14452-30-3) → 1-(3-iodophenyl)ethan-1-ol (79917-56-9)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 ℃;

DOI:10.1021/acs.orglett.0c02736

Reference yield:

1-(3-aminophenyl)ethanone (99-03-6) → 1-(3-iodophenyl)ethan-1-ol (79917-56-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid; copper; copper(II) sulfate; potassium iodide / water / 2 h / Reflux

1.2: 80 - 90 °C

2.1: Candida tenuis AKR₂B₅ xylose reductase [E_.⁽¹⁾C₁₁₁₇₅]; water; NADH / ethanol / 25 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

With sulfuric acid; Candida tenuis AKR₂B₅ xylose reductase [E_.⁽¹⁾C₁₁₁₇₅]; water; copper; copper(II) sulfate; NADH; potassium iodide; In ethanol; water;

DOI:10.1039/c1ob05510k

Reference yield:

m-iodobenzaldehyde (696-41-3) → 1-(3-iodophenyl)ethan-1-ol (79917-56-9)

Guidance literature:

With methyl magnesium iodide; diethyl ether;

upstream raw materials:

m-iodobenzaldehyde

3'-iodoacetophenone

1-(3-aminophenyl)ethanone

Downstream raw materials:

4-[3-(1-hydroxy-ethyl)-phenyl]-butyric acid ethyl ester

4-[3-(1-hydroxy-ethyl)-phenyl]-butyronitrile

1-(3-iodophenyl)ethyl acetate

2-fluoro-6-[1-(3-iodophenyl)-ethoxy]-benzonitrile

Refernces

• 1、 Estopi?á-Durán, Susana,McLean, Euan B.,Donnelly, Liam J.,Hockin, Bryony M.,Taylor, James E.. "Arylboronic Acid Catalyzed C-Alkylation and Allylation Reactions Using Benzylic Alcohols". supporting information. p. 7547 - 7551. Retrieved 2020/10/09.
• 2、 Vogl, Michael,Kratzer, Regina,Nidetzky, Bernd,Brecker, Lothar. "Candida tenuis xylose reductase catalysed reduction of acetophenones: The effect of ring-substituents on catalytic efficiency". experimental part. p. 5863 - 5870. Retrieved 2011/09/30.