(S)-8-Hydroxy-2-dipropylaminotetralin

Base Information

• Chemical Name: (S)-8-Hydroxy-2-dipropylaminotetralin
• CAS No.: 80300-10-3
• Molecular Formula: C16H25NO
• Molecular Weight: 247.37600
• Nikkaji Number: J567.595B
• Wikidata: Q27236979
• ChEMBL ID: CHEMBL88504
• Mol file: 80300-10-3.mol

Synonyms:(S)-8-Hydroxy-2-dipropylaminotetralin;UNII-0N1X9UW73U;CHEMBL88504;0N1X9UW73U;(2S)-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine;8-Hydroxy-2-(di-n-propylamino)tetralin, (-)-;(-)-2R-8-Hydroxy-2-(di-n-propylamino)tetralin;1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-, (7S)-;Dipropyl-(1,2,3,4-tetrahydro-naphthalen-2-yl)-amine;(S)-DPAT;BDBM50030021;(-)-8-hydroxy-2-(di-N-propylamino)tetralin;Q27236979;Dipropyl-(S)-1,2,3,4-tetrahydro-naphthalen-2-yl-amine

Chemical Property of (S)-8-Hydroxy-2-dipropylaminotetralin

Chemical Property:

• PSA: 23.47000
• LogP: 3.37150
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 231.198699802
• Heavy Atom Count: 17
• Complexity: 208

Purity/Quality:

99% ^*data from raw suppliers

(S)-(-)-8-HYDROXY-DPAT 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCN(CCC)C1CCC2=CC=CC=C2C1
• Isomeric SMILES: CCCN(CCC)[C@H]1CCC2=CC=CC=C2C1

Technology Process of (S)-8-Hydroxy-2-dipropylaminotetralin

There total 1 articles about (S)-8-Hydroxy-2-dipropylaminotetralin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-8-Methoxy-DPAT (119432-89-2) → (S)-8-hydroxy-2-dipropylaminotetralin (80300-10-3)

Guidance literature:

(S)-8-Methoxy-DPAT; With boron tribromide; In dichloromethane; at -40 - 20 ℃;

With water; sodium hydrogencarbonate; In dichloromethane;

DOI:10.1021/ol1022239

Reference yield:

(S)-8-hydroxy-2-dipropylaminotetralin (80300-10-3) → S-8-phenyl-2-(di-n-propylamino)tetralin

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / CH₂Cl₂ / -78 - 0 °C

2: tetrakis(triphenylphosphine)palladium⁽⁰⁾, LiCl, 2,6-di-tert-butyl-4-methylphenol / dioxane; dimethylformamide / 24 h / 120 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; potassium carbonate; lithium chloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00078a012

Reference yield:

(S)-8-hydroxy-2-dipropylaminotetralin (80300-10-3) → ((S)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-yl)-phenyl-methanone

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / CH₂Cl₂ / -78 - 0 °C

2: LiCl, dichloro<1,1'-bis(diphenylphosphino)ferrocene>palladium, molecular sieves 4A, 2,6-di-tert-butyl-4-methylphenol / dimethylformamide / 14 h / 90 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 2,6-di-tert-butyl-4-methyl-phenol; 4 A molecular sieve; potassium carbonate; lithium chloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00078a012

upstream raw materials:

(S)-8-Methoxy-DPAT

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