(E)-1,3-bis(1,3-benzodioxol-5-yl)prop-2-en-1-one

Base Information

Chemical Name:(E)-1,3-bis(1,3-benzodioxol-5-yl)prop-2-en-1-one
CAS No.:76530-89-7
Molecular Formula:C₁₇H₁₂O₅
Molecular Weight:296.279
Hs Code.:2932999099
NSC Number:162494
ChEMBL ID:CHEMBL1946289
Mol file:76530-89-7.mol

Synonyms:76530-89-7;Bis(3,4-methylenedioxy)chalcone;(E)-1,3-bis(1,3-benzodioxol-5-yl)prop-2-en-1-one;2-Propen-1-one,1,3-bis(1,3-benzodioxol-5-yl)-;2-Propen-1-one, 1,3-bis(1,3-benzodioxol-5-yl)-, (E)-;88755-19-5;NSC162494;SCHEMBL108665;CHEMBL1946289;STK950812;AKOS002239936;NSC-162494;CS-0358026;SR-01000247528;SR-01000247528-1;(2E)-1,3-bis(1,3-benzodioxol-5-yl)prop-2-en-1-one;1,3-Bis(benzo[d][1,3]dioxol-5-yl)prop-2-en-1-one;2-Propen-1-one, 1,3-bis(1,3-benzodioxol-5-yl)-, (2E)-

Suppliers and Price of (E)-1,3-bis(1,3-benzodioxol-5-yl)prop-2-en-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Bis(3,4-methylenedioxy)chalcone
25mg
$ 130.00

Biosynth Carbosynth
Bis(3,4-methylenedioxy)chalcone
10 mg
$ 120.10

Biosynth Carbosynth
Bis(3,4-methylenedioxy)chalcone
50 mg
$ 396.50

Biosynth Carbosynth
Bis(3,4-methylenedioxy)chalcone
250 mg
$ 1310.00

Biosynth Carbosynth
Bis(3,4-methylenedioxy)chalcone
100 mg
$ 721.00

Biosynth Carbosynth
Bis(3,4-methylenedioxy)chalcone
25 mg
$ 218.50

American Custom Chemicals Corporation
BIS(3,4-METHYLENEDIOXY)CHALCONE 95.00%
250MG
$ 1686.30

American Custom Chemicals Corporation
BIS(3,4-METHYLENEDIOXY)CHALCONE 95.00%
25MG
$ 716.10

American Custom Chemicals Corporation
BIS(3,4-METHYLENEDIOXY)CHALCONE 95.00%
10MG
$ 315.00

AK Scientific
(E)-1,3-Bis(1,3-benzodioxol-5-yl)prop-2-en-1-one
250mg
$ 1818.00

Total 4 raw suppliers

Chemical Property of (E)-1,3-bis(1,3-benzodioxol-5-yl)prop-2-en-1-one

Chemical Property:

Vapor Pressure:9.42E-10mmHg at 25°C
Boiling Point:490.1°C at 760 mmHg
Flash Point:220.3°C
PSA：53.99000
Density:1.396g/cm³
LogP:3.04010
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:296.06847348
Heavy Atom Count:22
Complexity:448

Purity/Quality:

98% ^*data from raw suppliers

Bis(3,4-methylenedioxy)chalcone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1OC2=C(O1)C=C(C=C2)C=CC(=O)C3=CC4=C(C=C3)OCO4
Isomeric SMILES:C1OC2=C(O1)C=C(C=C2)/C=C/C(=O)C3=CC4=C(C=C3)OCO4
Uses Used for the treatment of amyloid diseases and synucleinopathies such as Alzheimer disease, type 2 diabetes, and Parkinson disease. Bis(3,4-methylenedioxy)chalcone is used for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes, and Parkinson's disease.

Technology Process of (E)-1,3-bis(1,3-benzodioxol-5-yl)prop-2-en-1-one

There total 3 articles about (E)-1,3-bis(1,3-benzodioxol-5-yl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 120-57-0,30024-74-9
piperonal

: 3162-29-6
1-(benzo[d][1,3]dioxol-6-yl)ethanone

: 76530-89-7
1,3-bis-benzo[1,3]dioxol-5-ylpropenone

Guidance literature:: With sodium hydroxide; In methanol; for 10h; Ambient temperature;
DOI:10.1055/s-1980-29155

Reference yield: 58.0%

: 120-57-0,30024-74-9
piperonal

: 3162-29-6
1-(benzo[d][1,3]dioxol-6-yl)ethanone

: 1240093-64-4
C₁₇H₁₄O₆

: 76530-89-7
1,3-bis-benzo[1,3]dioxol-5-ylpropenone

Guidance literature:: piperonal; 1-(benzo[d][1,3]dioxol-6-yl)ethanone; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

With titanium tetrachloride; In dichloromethane; at -25 - -10 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.06.037

Reference yield:

: C₁₇H₁₄O₅

: (E)-1,2-methylenedioxy-4-(3-(3,4-methylenedioxyphenyl)allyl)benzene

: 76530-89-7
1,3-bis-benzo[1,3]dioxol-5-ylpropenone

Guidance literature:: With bismuth(lll) trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1h; chemoselective reaction;
DOI:10.1016/j.tet.2017.05.006