Technology Process of desmethylazelastine
There total 6 articles about desmethylazelastine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,1-dimethylethyl 4-[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]hexahydro-1H-azepine-1-carboxylate;
With
hydrogenchloride;
In
1,4-dioxane;
at 20 ℃;
for 1.5h;
With
ammonia;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3.58 h / -20 - 20 °C
2: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C
With
hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium acetate / 1-methyl-pyrrolidin-2-one / 48 h / 200 °C
2.1: hydrazine / ethanol / 15 h / 85 °C
2.2: 2 h / 2 °C
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3.58 h / -20 - 20 °C
4.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C
With
hydrogenchloride; di-isopropyl azodicarboxylate; sodium acetate; triphenylphosphine; hydrazine;
In
tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol;
