Cyclopentanecarboxylic acid, 2-[[(1S)-1-phenylethyl](phenylmethyl)amino]-3-(phenylmethyl)-, 1,1-dimethylethyl ester, (1R,2S,3S)-

Base Information Edit

Chemical Name:Cyclopentanecarboxylic acid, 2-[[(1S)-1-phenylethyl](phenylmethyl)amino]-3-(phenylmethyl)-, 1,1-dimethylethyl ester, (1R,2S,3S)-
CAS No.:816444-33-4
Molecular Formula:C32H39NO2
Molecular Weight:469.667
Hs Code.:
Mol file:816444-33-4.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclopentanecarboxylic acid, 2-[[(1S)-1-phenylethyl](phenylmethyl)amino]-3-(phenylmethyl)-, 1,1-dimethylethyl ester, (1R,2S,3S)- Edit

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MSDS Files:: SDS file from LookChem

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Technology Process of Cyclopentanecarboxylic acid, 2-[[(1S)-1-phenylethyl](phenylmethyl)amino]-3-(phenylmethyl)-, 1,1-dimethylethyl ester, (1R,2S,3S)-

There total 2 articles about Cyclopentanecarboxylic acid, 2-[[(1S)-1-phenylethyl](phenylmethyl)amino]-3-(phenylmethyl)-, 1,1-dimethylethyl ester, (1R,2S,3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 816444-14-1
tert-butyl (RS)-3-benzyl-cyclopent-1-enecarboxylate

: 17480-69-2
(S)-N-benzyl-1-phenylethylamine

: tert-butyl (R)-3-benzylcyclopentene-1-carboxylate

: tert-butyl (1S,2R,3R,αS)-3-benzyl-2-(N-benzyl-N-α-methylbenzylamino)-cyclopentane-1-carboxylate

: 820236-49-5
tert-butyl (1S,2S,3S,αS)-3-benzyl-2-(N-benzyl-N-α-methylbenzylamino)-cyclopentane-1-carboxylate

: 816444-33-4
tert-butyl (1R,2S,3S,αS)-3-benzyl-2-(N-benzyl-N-α-methylbenzylamino)-cyclopentane-1-carboxylate

Guidance literature:: (S)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

tert-butyl (RS)-3-benzyl-cyclopent-1-enecarboxylate; In tetrahydrofuran; hexane; at -78 ℃; for 3h;

With 2,6-di-tert-butylphenol; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.5h;
DOI:10.1039/b407559e

Reference yield: 39.0%

: 816444-14-1
tert-butyl (RS)-3-benzyl-cyclopent-1-enecarboxylate

: 17480-69-2
(S)-N-benzyl-1-phenylethylamine

: 134430-93-6,308273-67-8,680185-65-3
(R)-N-(3,4-dimethoxybenzyl)-N-(α-methylbenzyl)amine

: 816444-33-4
tert-butyl (1R,2S,3S,αS)-3-benzyl-2-(N-benzyl-N-α-methylbenzylamino)-cyclopentane-1-carboxylate

: tert-butyl (1S,2R,3R,αR)-3-benzyl-2-(N-3,4-dimethoxybenzyl-N-α-methylbenzylamino)cyclopentane-1-carboxylate

Guidance literature:: (S)-N-benzyl-1-phenylethylamine; (R)-N-(3,4-dimethoxybenzyl)-N-(α-methylbenzyl)amine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

tert-butyl (RS)-3-benzyl-cyclopent-1-enecarboxylate; In tetrahydrofuran; hexane; at -78 ℃; for 3h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane; at -78 - 30 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1016/j.tetasy.2010.12.007