1H-Azepine-1-acetic acid, 3-aminohexahydro-2-oxo-7-phenyl-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1H-Azepine-1-acetic acid, 3-aminohexahydro-2-oxo-7-phenyl-, 1,1-dimethylethyl ester
• CAS No.: 81867-81-4
• Molecular Formula: C18H26N2O3
• Molecular Weight: 318.41100

Synonyms:3-amino-1-t-butoxycarbonylmethyl-7-phenylperhydroazepin-2-one;

Chemical Property of 1H-Azepine-1-acetic acid, 3-aminohexahydro-2-oxo-7-phenyl-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 72.63000
• LogP: 3.04740

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Azepine-1-acetic acid, 3-aminohexahydro-2-oxo-7-phenyl-, 1,1-dimethylethyl ester

There total 2 articles about 1H-Azepine-1-acetic acid, 3-aminohexahydro-2-oxo-7-phenyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Azido-7-phenyl-(N-butoxycarbonylmethyl)-hexahydroazepin-2-one → 3-amino-7-phenyl-(N-t-butoxycarbonylmethyl)-hexahydroazepin-2-one (81867-81-4)

Guidance literature:

palladium; In ethanol;

Reference yield:

3-azido-1-t-butoxycarbonylmethyl-7-phenylperhydroazepin-2-one (81867-80-3) → 3-amino-7-phenyl-(N-t-butoxycarbonylmethyl)-hexahydroazepin-2-one (81867-81-4)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1016/j.bmcl.2007.06.062

Reference yield:

3-azido-1-t-butoxycarbonylmethyl-7-phenylperhydroazepin-2-one (81867-80-3) + 3-amino-7-phenyl-(N-t-butoxycarbonylmethyl)-hexahydroazepin-2-one (81867-81-4) → 1-t-butoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropyl)amino-7-phenylperhydroazepin-2-one

Guidance literature:

Pd-C; In ethanol;

upstream raw materials:

3-azido-1-t-butoxycarbonylmethyl-7-phenylperhydroazepin-2-one

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