Cyclohexanol, 3-(6-chloro-3-pyridinyl)-4-nitro-, (1R,3R,4R)-

Base Information

Chemical Name:Cyclohexanol, 3-(6-chloro-3-pyridinyl)-4-nitro-, (1R,3R,4R)-
CAS No.:820215-74-5
Molecular Formula:C₁₁H₁₃ClN₂O₃
Molecular Weight:256.689
Hs Code.:
DSSTox Substance ID:DTXSID00457676
Nikkaji Number:J2.112.031F
Wikidata:Q82280617

Synonyms:820215-74-5;Cyclohexanol, 3-(6-chloro-3-pyridinyl)-4-nitro-, (1R,3R,4R)-;DTXSID00457676;(1R,3R,4R)-3-(6-Chloro-3-pyridyl)-4-nitrocyclohexanol

Suppliers and Price of Cyclohexanol, 3-(6-chloro-3-pyridinyl)-4-nitro-, (1R,3R,4R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of Cyclohexanol, 3-(6-chloro-3-pyridinyl)-4-nitro-, (1R,3R,4R)-

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:256.0614700
Heavy Atom Count:17
Complexity:284

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(C(CC1O)C2=CN=C(C=C2)Cl)[N+](=O)[O-]
Isomeric SMILES:C1C[C@H]([C@H](C[C@@H]1O)C2=CN=C(C=C2)Cl)[N+](=O)[O-]

Technology Process of Cyclohexanol, 3-(6-chloro-3-pyridinyl)-4-nitro-, (1R,3R,4R)-

There total 6 articles about Cyclohexanol, 3-(6-chloro-3-pyridinyl)-4-nitro-, (1R,3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875553-02-9
allyl (4E)-2-[(1R)-1-(6-chloropyridin-3-yl)-2-nitroethyl]-5-methoxy-3-oxo-4-pentenoate

: 820215-74-5
(1R,3R,4R)-3-(6-chloropyridin-3-yl)-4-nitro-cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: KOH / ethanol / 0 °C

2.1: PPh₃; HCOOH; Et₃N / Pd(OAc)2 / tetrahydrofuran / 20 °C

2.2: L-selectride / tetrahydrofuran / -78 °C

2.3: NaOMe / 2-methyl-propan-2-ol

3.1: NaBH₃CN; AcOH / methanol / -20 °C

With potassium hydroxide; formic acid; sodium cyanoborohydride; acetic acid; triethylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran; methanol; ethanol;
DOI:10.2533/chimia.2007.269

Reference yield:

: 875553-03-0
(4S,5R,6S)-6-(6-chloropyridin-3-yl)-2-hydroxy-4-methoxy-5-nitrocyclohex-1-enecarboxylic acid allyl ester

: 820215-74-5
(1R,3R,4R)-3-(6-chloropyridin-3-yl)-4-nitro-cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: PPh₃; HCOOH; Et₃N / Pd(OAc)2 / tetrahydrofuran / 20 °C

1.2: L-selectride / tetrahydrofuran / -78 °C

1.3: NaOMe / 2-methyl-propan-2-ol

2.1: NaBH₃CN; AcOH / methanol / -20 °C

With formic acid; sodium cyanoborohydride; acetic acid; triethylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran; methanol;
DOI:10.2533/chimia.2007.269

Reference yield:

: 159153-42-1
2-chloro-5-trans-(β-nitrovinyl)pyridine

: 820215-74-5
(1R,3R,4R)-3-(6-chloropyridin-3-yl)-4-nitro-cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1R,2R)-1-[[3',5'-(CF₃)2-C₆H₃]-NH-C(S)-NH]-2-NMe₂-cC₆H₁₀ / toluene / 0 °C

2.1: KOH / ethanol / 0 °C

3.1: PPh₃; HCOOH; Et₃N / Pd(OAc)2 / tetrahydrofuran / 20 °C

3.2: L-selectride / tetrahydrofuran / -78 °C

3.3: NaOMe / 2-methyl-propan-2-ol

4.1: NaBH₃CN; AcOH / methanol / -20 °C

With potassium hydroxide; formic acid; sodium cyanoborohydride; acetic acid; triethylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran; methanol; ethanol; toluene; 1.1: Michael addition;
DOI:10.2533/chimia.2007.269