2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-2-(1H-indol-3 -yl)-1-methylethyl]amino]ethyl]phenyl]-

Base Information

Chemical Name:2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-2-(1H-indol-3 -yl)-1-methylethyl]amino]ethyl]phenyl]-
CAS No.:820216-46-4
Molecular Formula:C29H39N3O3S2Si
Molecular Weight:569.864
Hs Code.:

Synonyms:

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Chemical Property of 2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-2-(1H-indol-3 -yl)-1-methylethyl]amino]ethyl]phenyl]-

Chemical Property:

PSA：119.84000
LogP:8.85860

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-2-(1H-indol-3 -yl)-1-methylethyl]amino]ethyl]phenyl]-

There total 6 articles about 2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-2-(1H-indol-3 -yl)-1-methylethyl]amino]ethyl]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 7795-52-0,304-54-1
(-)-alpha-Methyltryptamine

: 776302-68-2
(R)-N-{3-[2-bromo-1-(tert-butyldimethylsilyloxy)ethyl]phenyl}(2-thiophene)sulfonamide

: 820216-46-4
thiophene-2-sulfonic acid (3-{1-(tert-butyl-dimethyl-silanyloxy)-2-[2-(1H-indol-3-yl)-1-methyl-ethylamino]-ethyl}-phenyl)-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; potassium iodide; In acetonitrile; for 48h; Heating;
DOI:10.1016/j.bmc.2004.10.032

Reference yield:

: 2227-64-7
3'-nitro-2-bromoacetophenone

: 820216-46-4
thiophene-2-sulfonic acid (3-{1-(tert-butyl-dimethyl-silanyloxy)-2-[2-(1H-indol-3-yl)-1-methyl-ethylamino]-ethyl}-phenyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / (R)-2-methyl-CBS-oxazaborolidine; BH₃*THF / toluene / 2.5 h / 20 °C

2: 95 percent / KBr; imidazole / dimethylformamide / 18 h

3: H₂ / Pt/C / ethyl acetate / 6 h

4: 166 g / pyridine / CH₂Cl₂ / 0 - 20 °C

5: 60 percent / i-Pr₂NEt; KI / acetonitrile / 48 h / Heating

With pyridine; 1H-imidazole; borane-THF; hydrogen; N-ethyl-N,N-diisopropylamine; potassium iodide; potassium bromide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; platinum on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmc.2004.10.032

Reference yield:

: 193761-55-6
(R)-2-bromo-1-(3-nitrophenyl)ethan-1-ol

: 820216-46-4
thiophene-2-sulfonic acid (3-{1-(tert-butyl-dimethyl-silanyloxy)-2-[2-(1H-indol-3-yl)-1-methyl-ethylamino]-ethyl}-phenyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / KBr; imidazole / dimethylformamide / 18 h

2: H₂ / Pt/C / ethyl acetate / 6 h

3: 166 g / pyridine / CH₂Cl₂ / 0 - 20 °C

4: 60 percent / i-Pr₂NEt; KI / acetonitrile / 48 h / Heating

With pyridine; 1H-imidazole; hydrogen; N-ethyl-N,N-diisopropylamine; potassium iodide; potassium bromide; platinum on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2004.10.032