Technology Process of Cyclopentanecarboxylic acid,
3-(1,1-dimethylethyl)-2-[[(1S)-1-phenylethyl](phenylmethyl)amino]-,
1,1-dimethylethyl ester, (1S,2S,3S)-
There total 11 articles about Cyclopentanecarboxylic acid,
3-(1,1-dimethylethyl)-2-[[(1S)-1-phenylethyl](phenylmethyl)amino]-,
1,1-dimethylethyl ester, (1S,2S,3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-N-benzyl-1-phenylethylamine;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
tert-butyl (RS)-3-(1',1'-dimethyl)cyclopentene-1-carboxylate;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 3h;
DOI:10.1039/b407559e
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: NaH / dimethylformamide / 3 h / 20 °C
1.2: 71 percent / dimethylformamide / 12 h / 20 °C
2.1: 92 percent / NaBH4 / ethanol / 1 h / 0 °C
3.1: 86 percent / PPh3; DIAD / tetrahydrofuran / 20 °C
4.1: aq. KOH / methanol / 12 h / 60 °C
5.1: 1.70 g / H2SO4 / CH2Cl2 / -78 - 20 °C
6.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
6.2: tetrahydrofuran; hexane / 3 h / -78 °C
6.3: 100 percent / t-BuOK / 2-methyl-propan-2-ol; hexane / 3 h / Heating
With
potassium hydroxide; sodium tetrahydroborate; n-butyllithium; di-isopropyl azodicarboxylate; sulfuric acid; sodium hydride; triphenylphosphine;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b407559e
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ethanol / 3 h / Heating
2.1: 186 g / NaBH4 / 72 h / 20 °C
3.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
3.2: tetrahydrofuran; hexane / 3 h / -78 °C
3.3: 100 percent / t-BuOK / 2-methyl-propan-2-ol; hexane / 3 h / Heating
With
sodium tetrahydroborate; n-butyllithium;
In
tetrahydrofuran; ethanol; hexane;
DOI:10.1039/b407559e
