Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-[[(3,4-dichlorophenyl)methyl]methylamino]-6-fluoro-, diethyl ester, (1R,2R,3R,5R,6R)-

Base Information

Chemical Name:Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-[[(3,4-dichlorophenyl)methyl]methylamino]-6-fluoro-, diethyl ester, (1R,2R,3R,5R,6R)-
CAS No.:820244-72-2
Molecular Formula:C₂₀H₂₅Cl₂FN₂O₄
Molecular Weight:447.334
Hs Code.:

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid,
2-amino-3-[[(3,4-dichlorophenyl)methyl]methylamino]-6-fluoro-, diethyl
ester, (1R,2R,3R,5R,6R)-

Synonyms:

Suppliers and Price of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-[[(3,4-dichlorophenyl)methyl]methylamino]-6-fluoro-, diethyl ester, (1R,2R,3R,5R,6R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-[[(3,4-dichlorophenyl)methyl]methylamino]-6-fluoro-, diethyl ester, (1R,2R,3R,5R,6R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-[[(3,4-dichlorophenyl)methyl]methylamino]-6-fluoro-, diethyl ester, (1R,2R,3R,5R,6R)-

There total 9 articles about Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-[[(3,4-dichlorophenyl)methyl]methylamino]-6-fluoro-, diethyl ester, (1R,2R,3R,5R,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 820244-71-1
(1R,2R,3R,5R,6R)-2-(tert-butoxycarbonylamino)-3-[(3,4-dichlorobenzyl)(methyl)amino]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

: 820244-72-2
(1R,2R,3R,5R,6R)-2-amino-3-[(3,4-dichlorobenzyl)(methyl)amino]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 ℃;
DOI:10.1016/j.bmc.2005.12.061

Reference yield:

: 820244-66-4
(1R,2R,3R,5R,6R)-3-azido-2-(tert-butoxycarbonylamino)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

: 820244-72-2
(1R,2R,3R,5R,6R)-2-amino-3-[(3,4-dichlorobenzyl)(methyl)amino]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / hydrogen / Pd/C / ethanol / 12 h / 20 °C

2: 43 percent / pyridine / CHCl₃ / 19 h / 20 °C

3: 90 percent / K₂CO₃ / dimethylformamide / 72 h / 20 °C

4: HCl / ethyl acetate / 0 °C

With pyridine; hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.12.061

Reference yield:

: 820244-64-2
(1R,2R,3S,5R,6R)-2-(tert-butoxycarbonylamino)-6-fluoro-3-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

: 820244-72-2
(1R,2R,3R,5R,6R)-2-amino-3-[(3,4-dichlorobenzyl)(methyl)amino]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / pyridine / CH₂Cl₂ / 0 °C

2: 71 percent / sodium azide / dimethylformamide / 30 h / 20 - 30 °C

3: 60 percent / hydrogen / Pd/C / ethanol / 12 h / 20 °C

4: 43 percent / pyridine / CHCl₃ / 19 h / 20 °C

5: 90 percent / K₂CO₃ / dimethylformamide / 72 h / 20 °C

6: HCl / ethyl acetate / 0 °C

With pyridine; hydrogenchloride; sodium azide; hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.12.061