Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 3-[(3,4-dichlorobenzoyl)amino]-2-[[(1,1-dimethylethoxy)carbonyl]amino]- 6-fluoro-, diethyl ester, (1R,2R,3R,5R,6R)-

Base Information

Chemical Name:Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 3-[(3,4-dichlorobenzoyl)amino]-2-[[(1,1-dimethylethoxy)carbonyl]amino]- 6-fluoro-, diethyl ester, (1R,2R,3R,5R,6R)-
CAS No.:820244-74-4
Molecular Formula:C24H29Cl2FN2O7
Molecular Weight:547.408
Hs Code.:

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid,
3-[(3,4-dichlorobenzoyl)amino]-2-[[(1,1-dimethylethoxy)carbonyl]amino]-
6-fluoro-, diethyl ester, (1R,2R,3R,5R,6R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 3-[(3,4-dichlorobenzoyl)amino]-2-[[(1,1-dimethylethoxy)carbonyl]amino]- 6-fluoro-, diethyl ester, (1R,2R,3R,5R,6R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 3-[(3,4-dichlorobenzoyl)amino]-2-[[(1,1-dimethylethoxy)carbonyl]amino]- 6-fluoro-, diethyl ester, (1R,2R,3R,5R,6R)-

There total 6 articles about Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 3-[(3,4-dichlorobenzoyl)amino]-2-[[(1,1-dimethylethoxy)carbonyl]amino]- 6-fluoro-, diethyl ester, (1R,2R,3R,5R,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 820244-67-5
(1R,2R,3R,5R,6R)-3-amino-2-(tert-butoxycarbonylamino)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

: 3024-72-4
3,4-dichlorobenzoyl chloride

: 820244-74-4
(1R,2R,3R,5R,6R)-2-(tert-butoxycarbonylamino)-3-(3,4-dichlorobenzoylamino)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

Guidance literature:: With pyridine; In chloroform; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2005.12.061

Reference yield:

: 820244-66-4
(1R,2R,3R,5R,6R)-3-azido-2-(tert-butoxycarbonylamino)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

: 820244-74-4
(1R,2R,3R,5R,6R)-2-(tert-butoxycarbonylamino)-3-(3,4-dichlorobenzoylamino)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / hydrogen / Pd/C / ethanol / 12 h / 20 °C

2: 84 percent / pyridine / CHCl₃ / 3 h / 20 °C

With pyridine; hydrogen; palladium on activated charcoal; In ethanol; chloroform;
DOI:10.1016/j.bmc.2005.12.061

Reference yield:

: 820244-64-2
(1R,2R,3S,5R,6R)-2-(tert-butoxycarbonylamino)-6-fluoro-3-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

: 820244-74-4
(1R,2R,3R,5R,6R)-2-(tert-butoxycarbonylamino)-3-(3,4-dichlorobenzoylamino)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / pyridine / CH₂Cl₂ / 0 °C

2: 71 percent / sodium azide / dimethylformamide / 30 h / 20 - 30 °C

3: 60 percent / hydrogen / Pd/C / ethanol / 12 h / 20 °C

4: 84 percent / pyridine / CHCl₃ / 3 h / 20 °C

With pyridine; sodium azide; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.12.061