MDL-29951

Base Information

Chemical Name:MDL-29951
CAS No.:130798-51-5
Molecular Formula:C12H9Cl2NO4
Molecular Weight:302.11
Hs Code.:
Mol file:130798-51-5.mol

Synonyms:3-(2-Carboxy-4,6-dichloroindol-3-yl)propionic acid;3-(4,6-dichloro-2-carboxyindol-3-yl)propionic acid;1lev;

Suppliers and Price of MDL-29951

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MDL29951
25mg
$ 150.00

TRC
MDL29951
250mg
$ 1190.00

Medical Isotopes, Inc.
MDL29951
2.5 g
$ 2200.00

Medical Isotopes, Inc.
MDL29951
250 mg
$ 650.00

DC Chemicals
MDL29951 >98%
100 mg
$ 550.00

Crysdot
MDL-29951 98+%
10mg
$ 208.00

Crysdot
MDL-29951 98+%
5mg
$ 117.00

Crysdot
MDL-29951 98+%
50mg
$ 586.00

Crysdot
MDL-29951 98+%
100mg
$ 911.00

ChemScene
MDL-29951 99.53%
100mg
$ 1680.00

Total 24 raw suppliers

Chemical Property of MDL-29951

Chemical Property:

Melting Point:273-280℃
Boiling Point:582.5±45.0 °C(Predicted)
PKA:4.04±0.30(Predicted)
PSA：90.39000
Density:1.657±0.06 g/cm3(Predicted)
LogP:3.19010
Storage Temp.:2-8°C(protect from light)
Solubility.:Soluble in DMSO (up to 15 mg/ml with warming) or in Ethanol (up to 10 mg/ml).

Purity/Quality:

97% ^*data from raw suppliers

MDL29951 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description NMDA receptors are neuroreceptors that have binding sites for glycine or D-serine as well as L-glutamate. MDL 29951 is an antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM). It is functional both in vitro and in vivo. MDL 29951 blocks NMDA receptor-dependent convulsions in audiogenic seizure-susceptible DBA/2J mice. It is used to evaluate the role of the glycine site of the NMDA receptor in neurological signaling. MDL 29951 is also an agonist of the G protein-coupled receptor GPR17 (EC50 values range from 7 nM to 6 μM, depending on the assay). GPR17 is thought to be involved in oligodendrocyte differentiation and myelin formation/repair.

Technology Process of MDL-29951

There total 7 articles about MDL-29951 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 130829-27-5
ethyl 4,6-dichloro-3-(3-ethoxy-3-oxopropyl)-1H-indole-2-carboxylate

: 130798-51-5
3-(2-carboxy-4,6-dichloroindol-3-yl)propionic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jm00088a014

Reference yield:

: 611-10-9
2-ethoxycarbonyl-1-cyclopentanone

: 130798-51-5
3-(2-carboxy-4,6-dichloroindol-3-yl)propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) aq. HCl, sodium nitrite, 2.) sodium acetate / 1.) from 0 deg C to 5 deg C, 2.) water, from 0 deg C to RT, 75 min

2: H₂SO₄ / 24 h / Heating

3: p-toluenesulfonic acid / toluene / 2 h / Heating

4: 84 percent / aq. LiOH / tetrahydrofuran / Ambient temperature

With hydrogenchloride; lithium hydroxide; sulfuric acid; sodium acetate; toluene-4-sulfonic acid; sodium nitrite; In tetrahydrofuran; toluene;
DOI:10.1021/jm00088a014

Reference yield:

: 2-[(3,5-Dichloro-phenyl)-hydrazono]-hexanedioic acid 1-ethyl ester

: 130798-51-5
3-(2-carboxy-4,6-dichloroindol-3-yl)propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂SO₄ / 24 h / Heating

2: p-toluenesulfonic acid / toluene / 2 h / Heating

3: 84 percent / aq. LiOH / tetrahydrofuran / Ambient temperature

With lithium hydroxide; sulfuric acid; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;
DOI:10.1021/jm00088a014