Carbamic acid, [[4-fluoro-3-(4-piperidinyl)phenyl]methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [[4-fluoro-3-(4-piperidinyl)phenyl]methyl]-, 1,1-dimethylethyl ester
CAS No.:823195-19-3
Molecular Formula:C17H25FN2O2
Molecular Weight:308.396
Hs Code.:

Synonyms:(4-Fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester;(4-fluoro-3-piperidin-4-yl-benzyl)carbamic acid tert-butyl ester;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [[4-fluoro-3-(4-piperidinyl)phenyl]methyl]-, 1,1-dimethylethyl ester

Chemical Property:

Boiling Point:427.4±45.0 °C(Predicted)
PSA：50.36000
Density:1.093±0.06 g/cm3(Predicted)
LogP:4.03710

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [[4-fluoro-3-(4-piperidinyl)phenyl]methyl]-, 1,1-dimethylethyl ester

There total 1 articles about Carbamic acid, [[4-fluoro-3-(4-piperidinyl)phenyl]methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 866613-80-1
(4-fluoro-3-piperidin-4-yl-benzyl)carbamic acid tert-butyl ester acetate salt

: 823195-19-3
tert-butyl 4-fluoro-3-(piperidin-4-yl)benzylcarbamate

Guidance literature:: (4-fluoro-3-piperidin-4-yl-benzyl)carbamic acid tert-butyl ester acetate salt; With hydrogenchloride; In water; pH=5;

With sodium hydroxide; In water; pH=> 12;

Reference yield: 86.5%

: 866613-86-7
4-bromo-3-methyl-5-propoxy-thiophene-2-carboxylic acid

: 823195-19-3
tert-butyl 4-fluoro-3-(piperidin-4-yl)benzylcarbamate

: 866613-87-8
{3-[1-(4-bromo-3-methyl-5-propoxy-thiophene-2-carbonyl)-piperidin-4-yl]-4-fluoro-benzyl}carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield: 75.0%

: 823195-16-0
3-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-benzoic acid

: 823195-19-3
tert-butyl 4-fluoro-3-(piperidin-4-yl)benzylcarbamate

: 823195-20-6
(4-fluoro-3-{1-[3-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-benzoyl]-piperidin-4-yl}-benzyl)-carbamic acid tert-butyl ester

Guidance literature:: With O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; dipropylethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2004.09.065