1H-Pyrrole-1-hexanoyl chloride, 2,5-dihydro-2,5-dioxo-

Base Information

• Chemical Name: 1H-Pyrrole-1-hexanoyl chloride, 2,5-dihydro-2,5-dioxo-
• CAS No.: 82333-93-5
• Molecular Formula: C10H12ClNO3
• Molecular Weight: 229.663
• Mol file: 82333-93-5.mol

Synonyms:

Chemical Property of 1H-Pyrrole-1-hexanoyl chloride, 2,5-dihydro-2,5-dioxo-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole-1-hexanoyl chloride, 2,5-dihydro-2,5-dioxo-

There total 1 articles about 1H-Pyrrole-1-hexanoyl chloride, 2,5-dihydro-2,5-dioxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid (55750-53-3) → benzyl N-(4-aminophenethyl)-N-methyl-L-valinate dihydrochioride (82333-93-5)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 76.0%

H-Glu-NH-NH-BOC (118359-43-6) + benzyl N-(4-aminophenethyl)-N-methyl-L-valinate dihydrochioride (82333-93-5) → EMC-Glu-NH-NH-BOC (1049627-38-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield: 74.0%

tert-butyl N-methyl-N-<2-(methylamino)ethyl>carbamate (112257-19-9) + benzyl N-(4-aminophenethyl)-N-methyl-L-valinate dihydrochioride (82333-93-5) → tert-butyl 2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-methylhexanamido)ethyl(methyl)carbamate

Guidance literature:

In dichloromethane; at 20 ℃; Cooling with ice;

upstream raw materials:

2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid

Downstream raw materials:

maleimidocaproyl-NMeVal-Val-Dil-Dap-phosphonophenylalanine

maleimidocaproyl-NMeVal-Val-Dil-Dap-phosphonophenylalanine

MC-MMAF-tetrazole

N-(6-oxo-6-azidohexyl)maleimide

Refernces

• 1、 Huang, Hai,Liu, Manman,Liu, Yangzhong,Sheng, Yaping,Wu, Tiantian,Xiao, Haihua. "Clustered nanobody-drug conjugates for targeted cancer therapy". . p. 9344 - 9347. Retrieved 2020.
• 2、 Chen, Lixue,Chen, Yali,Ding, Yanfang,Gao, Meng,Li, Hang,Li, Lei,Li, Shengnan,Ma, Xiaodong,Qi, Yan,Wang, Changyuan,Xu, Ruping,Xu, Youwei,Zhang, Sitong. "Honokiol Prodrug Nanoparticles Based on in Situ Albumin Binding for Long Circulation and High Tumor Uptake". supporting information. p. 1589 - 1595. Retrieved 2021/10/12.
• 3、 Bonneaud, Céline,Burgess, Julia M.,Bongiovanni, Roberta,Joly-Duhamel, Christine,Friesen, Chadron M.. "Photopolymerization of maleimide perfluoropolyalkylethers without a photoinitiator". . p. 699 - 707. Retrieved 2019/01/04.