BETA-OXO-2-BROMO-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER

Base Information

Chemical Name:BETA-OXO-2-BROMO-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER
CAS No.:823809-86-5
Molecular Formula:C13H15BrO3
Molecular Weight:299.16000
Hs Code.:
Mol file:823809-86-5.mol

Synonyms:3-(2-Bromo-phenyl)-3-oxo-propionic acid tert-butyl ester;Benzenepropanoic acid, 2-bromo-b-oxo-, 1,1-dimethylethyl ester;

Suppliers and Price of BETA-OXO-2-BROMO-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Alichem
tert-Butyl3-(2-bromophenyl)-3-oxopropanoate
25g
$ 1391.78

Alichem
tert-Butyl3-(2-bromophenyl)-3-oxopropanoate
10g
$ 905.84

Total 1 raw suppliers

Chemical Property of BETA-OXO-2-BROMO-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER

Chemical Property:

Boiling Point:341.7±22.0 °C(Predicted)
PKA:9.87±0.46(Predicted)
PSA：43.37000
Density:1.340±0.06 g/cm3(Predicted)
LogP:3.36360

Purity/Quality:

≥99% ^*data from raw suppliers

tert-Butyl3-(2-bromophenyl)-3-oxopropanoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of BETA-OXO-2-BROMO-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER

There total 4 articles about BETA-OXO-2-BROMO-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 540-88-5
acetic acid tert-butyl ester

: 6091-64-1
2-bromobenzoic acid ethyl ester

: 823809-86-5
tert-butyl 2-bromo-β-oxobenzenepropanoate

Guidance literature:: acetic acid tert-butyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 0.333333h;

2-bromobenzoic acid ethyl ester; In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.1016/j.tet.2004.09.112

Reference yield:

: C₁₃H₁₇BrO₃

: 823809-86-5
tert-butyl 2-bromo-β-oxobenzenepropanoate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1002/chem.201406460

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 823809-86-5
tert-butyl 2-bromo-β-oxobenzenepropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 3.5 h / -78 °C / Inert atmosphere

2: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

With n-butyllithium; Dess-Martin periodane; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/chem.201406460