5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline, 6,7-dihydro-9,10-dime thoxy-7-methyl-

Base Information

• Chemical Name: 5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline, 6,7-dihydro-9,10-dime thoxy-7-methyl-
• CAS No.: 77784-22-6
• Molecular Formula: C₂₀H₁₉NO₄
• Molecular Weight: 337.375
• Mol file: 77784-22-6.mol

Synonyms:Dehydrocrebanine

Chemical Property of 5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline, 6,7-dihydro-9,10-dime thoxy-7-methyl-

Chemical Property:

• Vapor Pressure: 4.8E-12mmHg at 25°C
• Boiling Point: 547.6°C at 760 mmHg
• Flash Point: 167.2°C
• PSA: 40.16000
• Density: 1.312g/cm³
• LogP: 3.79620

Purity/Quality:

98%min ^*data from raw suppliers

Dehydrocrebanine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline, 6,7-dihydro-9,10-dime thoxy-7-methyl-

There total 9 articles about 5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline, 6,7-dihydro-9,10-dime thoxy-7-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(-)-crebanine (517-62-4,25127-29-1,79642-40-3) → dehydrocrebanine (77784-22-6)

Guidance literature:

With palladium 10% on activated carbon; In acetonitrile; for 6h; Inert atmosphere; Reflux;

DOI:10.3390/molecules21121555

Reference yield: 90.0%

9,10-Dimethoxy-5,6-dihydro-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinoline-7-carboxylic acid ethyl ester (188922-58-9) → dehydrocrebanine (77784-22-6)

Guidance literature:

With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; for 1.5h; Heating;

DOI:10.3987/com-96-7609

Reference yield:

Crebanine (517-62-4,25127-29-1,79642-40-3) → dehydrocrebanine (77784-22-6)

Guidance literature:

With iodine; sodium acetate; In 1,4-dioxane;

DOI:10.1016/S0031-9422(00)83953-9

upstream raw materials:

diazomethane

Crebanine

9,10-Dimethoxy-5,6-dihydro-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinoline-7-carboxylic acid ethyl ester

2-(6-Bromo-2,3-dimethoxyphenyl)acetyl chloride

Refernces

• 1、 Zhou, De-Min,Yue, Bao-Zhen,Cui, Ji-Qiao,Cai, Meng-Shen,Zhang, Li-He. "Total synthesis of sinomendine and its analogs". . p. 439 - 450. Retrieved 2007/10/03.