5-amino-3-(3,5-dimethoxyanilino)-1H-pyrazole-4-carbonitrile

Base Information

• Chemical Name: 5-amino-3-(3,5-dimethoxyanilino)-1H-pyrazole-4-carbonitrile
• CAS No.: 824397-66-2
• Molecular Formula: C₁₂H₁₃N₅O₂
• Molecular Weight: 259.268
• DSSTox Substance ID: DTXSID20587747
• Nikkaji Number: J2.462.190A
• Wikidata: Q82480257
• Mol file: 824397-66-2.mol

Synonyms:824397-66-2;5-amino-3-(3,5-dimethoxyanilino)-1H-pyrazole-4-carbonitrile;DTXSID20587747;3-Amino-5-((3,5-dimethoxyphenyl)amino)-1H-pyrazole-4-carbonitrile

Chemical Property of 5-amino-3-(3,5-dimethoxyanilino)-1H-pyrazole-4-carbonitrile

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 259.10692467
• Heavy Atom Count: 19
• Complexity: 332

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1)NC2=NNC(=C2C#N)N)OC

Technology Process of 5-amino-3-(3,5-dimethoxyanilino)-1H-pyrazole-4-carbonitrile

There total 1 articles about 5-amino-3-(3,5-dimethoxyanilino)-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3.5-dimethoxyaniline (10272-07-8) → 5-amino-3-(3,5-dimethoxyphenylamino)pyrazole-1H-4-carbonitrile (947155-02-4,824397-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / methanol / 15 h / Heating

2: 91 percent / hydrazine monohydrate / dimethylformamide / 6 h / 100 °C

With hydrazine hydrate; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.55.881

Reference yield: 92.0%

5-amino-3-(3,5-dimethoxyphenylamino)pyrazole-1H-4-carbonitrile (947155-02-4,824397-66-2) + methyl 3-oxohexanoate (30414-54-1) → 2-(3,5-dimethoxyphenylamino)-7-oxo-5-propyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile (824397-99-1)

Guidance literature:

With acetic acid; for 10h; Heating;

DOI:10.1248/cpb.55.881

Reference yield: 91.0%

5-amino-3-(3,5-dimethoxyphenylamino)pyrazole-1H-4-carbonitrile (947155-02-4,824397-66-2) + ethyl acetoacetate (141-97-9) → 2-(3,5-dimethoxyphenylamino)-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile (824397-74-2)

Guidance literature:

With acetic acid; for 10h; Heating;

DOI:10.1248/cpb.55.881

upstream raw materials:

3.5-dimethoxyaniline

Downstream raw materials:

5-cyclopropyl-2-(3,5-dimethoxyphenylamino)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

2-(3,5-dimethoxyphenylamino)-5-ethyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

2-(3,5-dimethoxyphenylamino)-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

2-(3,5-dimethoxyphenylamino)-5-isopropyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile