Cyclohexanecarboxylic acid, 4-[2-[[(1,1-dimethylethoxy)carbonyl]methylamino]ethyl]-, trans-

Base Information

Chemical Name:Cyclohexanecarboxylic acid, 4-[2-[[(1,1-dimethylethoxy)carbonyl]methylamino]ethyl]-, trans-
CAS No.:824430-04-8
Molecular Formula:C15H27NO4
Molecular Weight:285.384
Hs Code.:

Synonyms:

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Chemical Property of Cyclohexanecarboxylic acid, 4-[2-[[(1,1-dimethylethoxy)carbonyl]methylamino]ethyl]-, trans-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Cyclohexanecarboxylic acid, 4-[2-[[(1,1-dimethylethoxy)carbonyl]methylamino]ethyl]-, trans-

There total 6 articles about Cyclohexanecarboxylic acid, 4-[2-[[(1,1-dimethylethoxy)carbonyl]methylamino]ethyl]-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 553676-96-3
trans-[2-(4-hydroxymethylcyclohexyl)ethyl]methylcarbamic acid tert-butyl ester

: 824430-04-8
trans-4-[2-(tert-butoxycarbonylmethylamino)ethyl]cyclohexanecarboxylic acid

Guidance literature:: With sodium periodate; ruthenium(III) chloride monohydrate; In tetrachloromethane; water; acetonitrile; for 0.5h; Inert atmosphere;
DOI:10.1021/jm300256z

Reference yield:

: 180046-64-4
C₁₅H₂₉NOSi

: 824430-04-8
trans-4-[2-(tert-butoxycarbonylmethylamino)ethyl]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: platinum(IV) oxide; hydrogen / ethanol / 20 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 3.17 h / 20 °C

3: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

4: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: potassium carbonate / methanol / 2 h / 20 °C / Inert atmosphere

6: sodium periodate; ruthenium(III) chloride monohydrate / tetrachloromethane; water; acetonitrile / 0.5 h / Inert atmosphere

With pyridine; platinum(IV) oxide; sodium periodate; ruthenium(III) chloride monohydrate; hydrogen; sodium hydride; potassium carbonate; triethylamine; In methanol; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm300256z

Reference yield:

: 553676-91-8
trans-[4-(2-aminoethyl)cyclohexyl]methanol hydrochloride

: 824430-04-8
trans-4-[2-(tert-butoxycarbonylmethylamino)ethyl]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 3.17 h / 20 °C

2: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: potassium carbonate / methanol / 2 h / 20 °C / Inert atmosphere

5: sodium periodate; ruthenium(III) chloride monohydrate / tetrachloromethane; water; acetonitrile / 0.5 h / Inert atmosphere

With pyridine; sodium periodate; ruthenium(III) chloride monohydrate; sodium hydride; potassium carbonate; triethylamine; In methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm300256z