Azetidine, 2-hexyl-1-[(4-methylphenyl)sulfonyl]-3-phenyl-, (2R,3S)-

Base Information

Chemical Name:Azetidine, 2-hexyl-1-[(4-methylphenyl)sulfonyl]-3-phenyl-, (2R,3S)-
CAS No.:825601-59-0
Molecular Formula:C22H29NO2S
Molecular Weight:371.53600
Hs Code.:
DSSTox Substance ID:DTXSID40457433
Nikkaji Number:J2.113.112A
Wikidata:Q82280276

Synonyms:825601-59-0;Azetidine, 2-hexyl-1-[(4-methylphenyl)sulfonyl]-3-phenyl-, (2R,3S)-;DTXSID40457433;(2R,3S)-2-Hexyl-3-phenyl-1-tosylazetidine

Suppliers and Price of Azetidine, 2-hexyl-1-[(4-methylphenyl)sulfonyl]-3-phenyl-, (2R,3S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Azetidine, 2-hexyl-1-[(4-methylphenyl)sulfonyl]-3-phenyl-, (2R,3S)-

Chemical Property:

Melting Point:69 °C
Boiling Point:503.4±60.0 °C(Predicted)
PSA：45.76000
Density:1.114±0.06 g/cm3(Predicted)
LogP:6.14080
XLogP3:5.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:371.19190034
Heavy Atom Count:26
Complexity:513

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCCC1C(CN1S(=O)(=O)C2=CC=C(C=C2)C)C3=CC=CC=C3
Isomeric SMILES:CCCCCC[C@@H]1[C@H](CN1S(=O)(=O)C2=CC=C(C=C2)C)C3=CC=CC=C3

Technology Process of Azetidine, 2-hexyl-1-[(4-methylphenyl)sulfonyl]-3-phenyl-, (2R,3S)-

There total 5 articles about Azetidine, 2-hexyl-1-[(4-methylphenyl)sulfonyl]-3-phenyl-, (2R,3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[(R)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-heptyl]-4-methyl-benzenesulfonamide

: 825601-59-0
(2R,3S)-(-)-2-hexyl-3-phenyl-1-tosylazetidine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 72h;
DOI:10.1002/ejoc.200400473

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 825601-59-0
(2R,3S)-(-)-2-hexyl-3-phenyl-1-tosylazetidine

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / K₂CO₃ / CH₂Cl₂ / 14 h

2: H₂ / Pd/C / ethyl acetate

3: PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 72 h / 20 °C

With di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1002/ejoc.200400473

Reference yield:

: 825601-11-4
(2R,2S)-(-)-[3-benzyloxy-2-phenylpropylidene][2-(methoxymethyl)pyrrolidin-1-yl]amine

: 825601-59-0
(2R,3S)-(-)-2-hexyl-3-phenyl-1-tosylazetidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: CeCl₃ / tetrahydrofuran / 2 h / -78 °C

1.2: 93 percent / tetrahydrofuran / 2 h / -100 - -78 °C

2.1: BH₃*THF / tetrahydrofuran / Heating

2.2: 88 percent / aq. HCl / tetrahydrofuran / 2 h / Heating

3.1: 89 percent / K₂CO₃ / CH₂Cl₂ / 14 h

4.1: H₂ / Pd/C / ethyl acetate

5.1: PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 72 h / 20 °C

With cerium(III) chloride; borane-THF; di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1002/ejoc.200400473