Hexanal, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[(4-methoxyphenyl)methoxy]-, (3R)-

Base Information

• Chemical Name: Hexanal, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[(4-methoxyphenyl)methoxy]-, (3R)-
• CAS No.: 825612-52-0
• Molecular Formula: C20H34O4Si
• Molecular Weight: 366.573
• Mol file: 825612-52-0.mol

Synonyms:(R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-hexanal;

Chemical Property of Hexanal, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[(4-methoxyphenyl)methoxy]-, (3R)-

Chemical Property:

• PSA: 44.76000
• LogP: 4.97140

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hexanal, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[(4-methoxyphenyl)methoxy]-, (3R)-

There total 3 articles about Hexanal, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[(4-methoxyphenyl)methoxy]-, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-6-[(4-methoxybenzyl)oxy]-hexanoate (825612-51-9) → (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-6-[(4-methoxybenzyl)oxy]-hexanal (825612-52-0)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 2h;

DOI:10.1002/chem.200400617

Reference yield:

ethyl (3RS)-3-hydroxy-6-[(4-methoxybenzyl)oxy]hexanoate → (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-6-[(4-methoxybenzyl)oxy]-hexanal (825612-52-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0 - 23 °C

2: 83 percent / DIBAL / CH₂Cl₂ / 2 h / -78 °C

With 2,6-dimethylpyridine; diisobutylaluminium hydride; In dichloromethane;

DOI:10.1002/chem.200400617

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) → (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-6-[(4-methoxybenzyl)oxy]-hexanal (825612-52-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0 - 23 °C

2: 83 percent / DIBAL / CH₂Cl₂ / 2 h / -78 °C

With 2,6-dimethylpyridine; diisobutylaluminium hydride; In dichloromethane;

DOI:10.1002/chem.200400617

upstream raw materials:

ethyl (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-6-[(4-methoxybenzyl)oxy]-hexanoate

t-butyldimethylsiyl triflate

Downstream raw materials:

(4S)-4-benzyl-3-{(2S,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-3-hydroxy-8-[(4-methoxybenzyl)oxy]-2-methyloctanoyl}-1,3-oxazolidin-2-one

(4S)-4-benzyl-3-((2S)-2-{(1R,3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxy-6-[(4-methoxybenzyl)oxy]hexyl}-4-pentenoyl)-1,3-oxazolidin-2-one

(4R,6R,7S)-1-[(4-methoxybenzyl)oxy]-6(methoxymethoxy)-7-methyl-9-decen-4-ol

(4R,6R)-4-{[tert-butyl(dimethyl)silyl]oxy}-1-[(4-methoxybenzyl)oxy]-6-(methoxymethoxy)-7-methyloct-7-ene