L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosylglycylglycyl-N-(1-formyl-3-meth ylbutyl)-, (S)-

Base Information

• Chemical Name: L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosylglycylglycyl-N-(1-formyl-3-meth ylbutyl)-, (S)-
• CAS No.: 82692-87-3
• Molecular Formula: C₃₃H₄₅N₅O₈
• Molecular Weight: 639.749
• Mol file: 82692-87-3.mol

Synonyms:

Chemical Property of L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosylglycylglycyl-N-(1-formyl-3-meth ylbutyl)-, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosylglycylglycyl-N-(1-formyl-3-meth ylbutyl)-, (S)-

There total 4 articles about L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosylglycylglycyl-N-(1-formyl-3-meth ylbutyl)-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

Boc-L-Tyr-Gly-Gly-L-Phe-L-Leu-alcohol (82689-22-3) → Boc-L-Tyr-Gly-Gly-L-Phe-L-Leu-al (82692-87-3)

Guidance literature:

With sulfur trioxide pyridine complex; triethylamine; In dimethyl sulfoxide; for 0.166667h; Ambient temperature;

DOI:10.1248/cpb.30.1921

Reference yield:

Boc-L-Tyr-Gly-Gly-L-Phe (64848-07-3) → Boc-L-Tyr-Gly-Gly-L-Phe-L-Leu-al (82692-87-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / diethyl phosphorocyanidate

2: NaBH₄, LiCl / ethanol; tetrahydrofuran

3: 61 percent / sulfur trioxide-pyridine complex, triethylamine / dimethylsulfoxide / 0.17 h / Ambient temperature

With sodium tetrahydroborate; diethyl cyanophosphonate; sulfur trioxide pyridine complex; triethylamine; lithium chloride; In tetrahydrofuran; ethanol; dimethyl sulfoxide;

DOI:10.1248/cpb.30.1921

Reference yield:

methyl (L)-leucinate hydrochloride (7517-19-3) → Boc-L-Tyr-Gly-Gly-L-Phe-L-Leu-al (82692-87-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / diethyl phosphorocyanidate

2: NaBH₄, LiCl / ethanol; tetrahydrofuran

3: 61 percent / sulfur trioxide-pyridine complex, triethylamine / dimethylsulfoxide / 0.17 h / Ambient temperature

With sodium tetrahydroborate; diethyl cyanophosphonate; sulfur trioxide pyridine complex; triethylamine; lithium chloride; In tetrahydrofuran; ethanol; dimethyl sulfoxide;

DOI:10.1248/cpb.30.1921

upstream raw materials:

Boc-L-Tyr-Gly-Gly-L-Phe-L-Leu-alcohol

Boc-L-Tyr-Gly-Gly-L-Phe

methyl (L)-leucinate hydrochloride

Boc-L-Tyr-Gly-Gly-L-Phe-L-Leu-OMe