11-Methoxy-N-n-propylnoraporphine

Base Information

• Chemical Name: 11-Methoxy-N-n-propylnoraporphine
• CAS No.: 53581-14-9
• Molecular Formula: C20H23NO
• Molecular Weight: 0
• Mol file: 53581-14-9.mol

Synonyms:11-methoxy-N-n-propylnoraporphine

Chemical Property of 11-Methoxy-N-n-propylnoraporphine

Chemical Property:

• Vapor Pressure: 7.47E-08mmHg at 25°C
• Boiling Point: 437.5°Cat760mmHg
• Flash Point: 128°C
• PSA: 12.47000
• Density: 1.099g/cm³
• LogP: 4.16540

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 11-Methoxy-N-n-propylnoraporphine

There total 11 articles about 11-Methoxy-N-n-propylnoraporphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(R)-(-)-10-O-(1-phenyltetrazol-5-yl)-11-methoxy-N-n-propylnoraporphine (121617-51-4) → (R)-(-)-11-methoxy-N-n-propylnoraporphine (99755-61-0,53581-14-9)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; at 45 ℃; for 24h; under 2327.2 Torr;

DOI:10.1021/jm00128a044

Reference yield:

(R)-(-)-10-O-(1-phenyltetrazol-5-yl)-11-methoxy-N-n-propylnoraporphine hydrochloride (83207-96-9) → (R)-(-)-11-methoxy-N-n-propylnoraporphine (99755-61-0,53581-14-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 264h; under 2327.2 Torr; Ambient temperature;

DOI:10.1021/jo00143a050

Reference yield:

Trifluoro-methanesulfonic acid (R)-11-methoxy-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-10-yl ester (179952-74-0) → (R)-(-)-11-methoxy-N-n-propylnoraporphine (99755-61-0,53581-14-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; formic acid; tributyl-amine; 1,3-bis-(diphenylphosphino)propane; In N,N-dimethyl-formamide; at 80 ℃; for 18h;

DOI:10.1021/jm960189i

upstream raw materials:

1-(2-amino-3-methoxybenzyl)-2-propyl-1,2,3,4-tetrahydroisoquinoline

(R)-(-)-10-O-(1-phenyltetrazol-5-yl)-11-methoxy-N-n-propylnoraporphine hydrochloride

(R)-(-)-10-O-(1-phenyltetrazol-5-yl)-11-methoxy-N-n-propylnoraporphine

Trifluoro-methanesulfonic acid (R)-11-methoxy-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-10-yl ester

Refernces

• 1、 Cannon,Jackson,Long,Leonard,Bhatnagar. "5-HT1A-receptor antagonism: N-alkyl derivatives of (R)-(-)-8,11-dimethoxynoraporphine.". . p. 1959 - 1962. Retrieved 2007/10/02.
• 2、 Ram, Vishnu J.,Neumeyer, John L.. "Aporphines. 42. Synthesis of (R)-(-)-11-Hydroxyaporphines from Morphine". . p. 4372 - 4374. Retrieved 2007/10/02.