Phosphonic acid, [(2R)-2-amino-2-(2-bromophenyl)ethyl]-, diethyl ester

Base Information

Chemical Name:Phosphonic acid, [(2R)-2-amino-2-(2-bromophenyl)ethyl]-, diethyl ester
CAS No.:827320-99-0
Molecular Formula:C12H19BrNO3P
Molecular Weight:336.166
Hs Code.:
DSSTox Substance ID:DTXSID30463907
Nikkaji Number:J2.112.923B
Wikidata:Q82289000

Synonyms:827320-99-0;Phosphonic acid, [(2R)-2-amino-2-(2-bromophenyl)ethyl]-, diethyl ester;DTXSID30463907

Suppliers and Price of Phosphonic acid, [(2R)-2-amino-2-(2-bromophenyl)ethyl]-, diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phosphonic acid, [(2R)-2-amino-2-(2-bromophenyl)ethyl]-, diethyl ester

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:335.02859
Heavy Atom Count:18
Complexity:281

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOP(=O)(CC(C1=CC=CC=C1Br)N)OCC
Isomeric SMILES:CCOP(=O)(C[C@@H](C1=CC=CC=C1Br)N)OCC

Technology Process of Phosphonic acid, [(2R)-2-amino-2-(2-bromophenyl)ethyl]-, diethyl ester

There total 2 articles about Phosphonic acid, [(2R)-2-amino-2-(2-bromophenyl)ethyl]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 450406-82-3
[(S)-2-(2-Bromo-phenyl)-2-hydroxy-ethyl]-phosphonic acid diethyl ester

: 827320-99-0
diethyl (2R)-β-amino-β-(o-bromophenyl)ethylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: Ph₃P; DEAD; HN₃ / CH₂Cl₂; CHCl₃ / -15 - 20 °C

2: benzene / 2 h / 20 °C

3: H₂O / 4 h / 55 °C

With tris-(2-chloro-ethyl)-amine; water; triphenylphosphine; diethylazodicarboxylate; In dichloromethane; chloroform; benzene; 1: Mitsunobu reaction;
DOI:10.1002/ejoc.200400420

Reference yield:

: [(R)-2-Azido-2-(2-bromo-phenyl)-ethyl]-phosphonic acid diethyl ester

: 827320-99-0
diethyl (2R)-β-amino-β-(o-bromophenyl)ethylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / 2 h / 20 °C

2: H₂O / 4 h / 55 °C

With water; In benzene;
DOI:10.1002/ejoc.200400420