Carbamic acid, [(1S)-2-oxo-1-[[1-(phenylmethyl)-1H-imidazol-4-yl]methyl]-2-[[2-[(triphen ylmethyl)thio]ethyl]amino]ethyl]-, 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [(1S)-2-oxo-1-[[1-(phenylmethyl)-1H-imidazol-4-yl]methyl]-2-[[2-[(triphen ylmethyl)thio]ethyl]amino]ethyl]-, 9H-fluoren-9-ylmethyl ester
• CAS No.: 827348-54-9
• Molecular Formula: C49H44N4O3S
• Molecular Weight: 768.979

Synonyms:

Chemical Property of Carbamic acid, [(1S)-2-oxo-1-[[1-(phenylmethyl)-1H-imidazol-4-yl]methyl]-2-[[2-[(triphen ylmethyl)thio]ethyl]amino]ethyl]-, 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1S)-2-oxo-1-[[1-(phenylmethyl)-1H-imidazol-4-yl]methyl]-2-[[2-[(triphen ylmethyl)thio]ethyl]amino]ethyl]-, 9H-fluoren-9-ylmethyl ester

There total 2 articles about Carbamic acid, [(1S)-2-oxo-1-[[1-(phenylmethyl)-1H-imidazol-4-yl]methyl]-2-[[2-[(triphen ylmethyl)thio]ethyl]amino]ethyl]-, 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Fmoc-His(1-Bzl)-OH (84030-19-3) + 2-amino tritylthio ethane (1095-85-8) → [2-(1-benzyl-1H-imidazol-4-yl)-1-(2-tritylsulfanyl-ethylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (827348-54-9)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; for 4h; pH=13;

DOI:10.1021/ol048853+

Reference yield:

trityl chloride (76-83-5) → [2-(1-benzyl-1H-imidazol-4-yl)-1-(2-tritylsulfanyl-ethylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (827348-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂ / 0.5 h / 63

2: 86 percent / EDC; HOBt; DIPRA / 4 h / pH 13

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ol048853+

Reference yield:

[2-(1-benzyl-1H-imidazol-4-yl)-1-(2-tritylsulfanyl-ethylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (827348-54-9) → 2-amino-3-(1-benzyl-1H-imidazol-4-yl)-N-(2-tritylsulfanyl-ethyl)-propionamide

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; for 0.5h;

DOI:10.1021/ol048853+

upstream raw materials:

Fmoc-His(1-Bzl)-OH

2-amino tritylthio ethane

trityl chloride

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