Chemical Property of 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone
Chemical Property:
- Vapor Pressure:5.24E-08mmHg at 25°C
- Melting Point:151℃
- Boiling Point:441.9°Cat760mmHg
- PKA:9.46±0.40(Predicted)
- Flash Point:221.1°C
- PSA：80.22000
- Density:1.4g/cm3
- LogP:1.69220
- Storage Temp.:−20°C
- Sensitive.:Light Sensitive
- Solubility.:DMSO: >10 mg/mL
- XLogP3:1.9
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:2
- Exact Mass:259.07793322
- Heavy Atom Count:18
- Complexity:373
- Purity/Quality:
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99%, *data from raw suppliers
Necrostatin-1 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Statements:
36/37/39
- Safety Statements:
36/37/39
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
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Description
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 (4311-88-0) is an inhibitor of necroptosis (non-apoptotic cell death pathway; EC50 = 494 nM).1 It is an ATP-competitive death domain receptor-associated adaptor kinase (RIP1) inhibitor (EC50 = 182 nM).2 Necrostatin-1 displays a protective effect in a mouse model of ischemic brain injury1, inhibits myocardial cell death and reduces infarct size in various mouse heart models3 and inhibits glutamate-induced oxytosis in HT-22 cells4.
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Uses
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of
TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction. Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.
