BAY-m 4798

Base Information

• Chemical Name: BAY-m 4798
• CAS No.: 89288-25-5
• Molecular Formula: C₁₇H₁₄N₂O₆
• Molecular Weight: 342.308
• Mol file: 89288-25-5.mol

Synonyms:

Chemical Property of BAY-m 4798

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BAY-m 4798

There total 11 articles about BAY-m 4798 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.32%

C27H25N3O7 → ethyl-2-methyl-4-(3-nitrophenyl)-5-oxo-5,7-dihydrofuro<3,4-b>3-pyridinecarboxylate (89288-25-5)

Guidance literature:

With boron tribromide; In dichloromethane; chloroform; at -20 - -10 ℃; for 4h;

Reference yield: 72.0%

ethyl-2-methyl-4-(3-nitrophenyl)-5-oxo-1,4,5,7-tetrahydrofuro<3,4-b>-3-pyridinecarboxylate (89267-47-0) → ethyl-2-methyl-4-(3-nitrophenyl)-5-oxo-5,7-dihydrofuro<3,4-b>3-pyridinecarboxylate (89288-25-5)

Guidance literature:

With chromium(VI) oxide; In acetic acid; for 0.5h; Heating;

Reference yield:

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester (39562-70-4) → SL 5721 (64603-72-1) + 5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (74936-72-4) + methyl 2-methyl-4-(3-nitrophenyl)-5-oxo-5,7-dihydro-furo<3,4-b>pyridine-3-carboxylate (64603-74-3) + ethyl-2-methyl-4-(3-nitrophenyl)-5-oxo-5,7-dihydrofuro<3,4-b>3-pyridinecarboxylate (89288-25-5) + (R)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl) ester 5-methyl ester (138135-46-3) + (S)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl) ester 5-methyl ester (138135-45-2)

Guidance literature:

biotransformation in rat, dog, and mouse (in vivo and in vitro);

upstream raw materials:

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

ethyl-2-methyl-4-(3-nitrophenyl)-5-oxo-1,4,5,7-tetrahydrofuro<3,4-b>-3-pyridinecarboxylate

ethyl (E)-3-aminobut-2-enoate

ethyl 4-acetoxyacetoacetate

Downstream raw materials:

C₁₇H₁₆N₂O₇

Refernces

• 1、 Goerlitzer,Bartke. "3-(Nitrobenzylidene)-2,4(3H,5H)-furandiones in the Hantzsch pyridine synthesis, part 1.: A new approach to furo[3,4-b]pyridines". . p. 672 - 678. Retrieved 2007/10/03.
• 2、 Meyer,Scherling,Karl. "Nitrendipine: Identification and synthesis of main metabolites". . p. 1528 - 1534. Retrieved 2007/10/02.