1-morpholin-4-yl-2-tetralin-2-yl-ethanethione

Base Information

• Chemical Name: 1-morpholin-4-yl-2-tetralin-2-yl-ethanethione
• CAS No.: 5452-58-4
• Molecular Formula: C16H21 N O S
• Molecular Weight: 275.41
• Hs Code.: 2934999090
• Mol file: 5452-58-4.mol

Synonyms:Morpholine,4-[2-(5,6,7,8-tetrahydro-2-naphthalenyl)-1-thioxoethyl]- (9CI); NSC 18944

Chemical Property of 1-morpholin-4-yl-2-tetralin-2-yl-ethanethione

Chemical Property:

• Vapor Pressure: 1.37E-07mmHg at 25°C
• Boiling Point: 429.7°Cat760mmHg
• Flash Point: 213.7°C
• PSA: 44.56000
• Density: 1.17g/cm³
• LogP: 2.70540

Purity/Quality:

1-MORPHOLIN-4-YL-2-(5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)ETHANETHIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-morpholin-4-yl-2-tetralin-2-yl-ethanethione

There total 2 articles about 1-morpholin-4-yl-2-tetralin-2-yl-ethanethione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

morpholine (110-91-8,99108-56-2) + 6-Acetyl-1,2,3,4-tetrahydronaphthalene (774-55-0) → 1-morpholin-4-yl-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-ethanethione (5452-58-4)

Guidance literature:

With sulfur; for 24h; Heating;

DOI:10.1021/jm00047a006

Reference yield:

tetralin (119-64-2) → 1-morpholin-4-yl-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-ethanethione (5452-58-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / AlCl₃ / CH₂Cl₂ / 15 h / Ambient temperature

2: 80 percent / S / 24 h / Heating

With aluminium trichloride; sulfur; In dichloromethane;

DOI:10.1021/jm00047a006

Reference yield: 75.0%

1-morpholin-4-yl-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-ethanethione (5452-58-4) → 5,6,7,8-tetrahydro-2-naphthylacetic acid (13052-99-8)

Guidance literature:

With potassium hydroxide; for 20h; Heating;

DOI:10.1021/jm00047a006

upstream raw materials:

morpholine

6-Acetyl-1,2,3,4-tetrahydronaphthalene

tetralin

Downstream raw materials:

5,6,7,8-tetrahydro-2-naphthylacetic acid