4-Thiazolecarboxamide, 2-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]-N-methyl-

Base Information

Chemical Name:4-Thiazolecarboxamide, 2-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]-N-methyl-
CAS No.:828936-88-5
Molecular Formula:C27H28N2O2SSi
Molecular Weight:472.67400
Hs Code.:

Synonyms:2-[2-(tert-Butyl-diphenyl-silanyloxy)-phenyl]-thiazole-4-carboxylic acid methylamide;

Suppliers and Price of 4-Thiazolecarboxamide, 2-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]-N-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Thiazolecarboxamide, 2-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]-N-methyl-

Chemical Property:

PSA：79.46000
LogP:5.49940

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Thiazolecarboxamide, 2-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]-N-methyl-

There total 1 articles about 4-Thiazolecarboxamide, 2-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]phenyl]-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 554409-14-2
2-(2-hydroxy-phenyl)-4,5-dihydro-thiazole-4-carboxylic acid methoxy-methyl-amide

: 828936-88-5
2'-[2-(t-butyldiphenylsiloxy)-phenyl]-thiazole-4'-N-methylcarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / sodium hydride / methanol / 0.33 h / 23 °C

2: 100 percent / triethylamine / CH₂Cl₂ / 16 h / 20 °C

With sodium hydride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.tet.2004.10.030

Reference yield: 74.0%

: 18598-63-5
L-cysteine methyl ester hydrochloride

: 828936-88-5
2'-[2-(t-butyldiphenylsiloxy)-phenyl]-thiazole-4'-N-methylcarboxamide

: 828936-89-6
2'-[2-(t-butyldiphenylsilyloxy)-phenyl]-4'',5''-dihydro-[2'',4']bisthiazolyl-4''-carboxylic acid methyl ester

Guidance literature:: With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -30 - 20 ℃;
DOI:10.1016/j.tet.2004.10.030

Reference yield:

: 828936-88-5
2'-[2-(t-butyldiphenylsiloxy)-phenyl]-thiazole-4'-N-methylcarboxamide

: 828936-90-9
2'-(2-hydroxyphenyl)-4'',5''-dihydro-[2'',4']bisthiazolyl-4''-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / pyridine; triflic anhydride / CH₂Cl₂ / -30 - 20 °C

2: 79 percent / TBAF / CH₂Cl₂; tetrahydrofuran / 0.33 h / 20 °C

With pyridine; trifluoromethylsulfonic anhydride; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2004.10.030