methyl 2-chloro-2-cyclopropylideneacetate

Base Information

• Chemical Name: methyl 2-chloro-2-cyclopropylideneacetate
• CAS No.: 82979-45-1
• Molecular Formula: C6H7ClO2
• Molecular Weight: 146.573
• Hs Code.: 2916200090
• Mol file: 82979-45-1.mol

Synonyms:methyl 2-chloro-2-cyclopropylideneacetate;

Chemical Property of methyl 2-chloro-2-cyclopropylideneacetate

Chemical Property:

• PSA: 26.30000
• LogP: 1.44610
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-chloro-2-cyclopropylideneacetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-chloro-2-cyclopropylideneacetate

There total 9 articles about methyl 2-chloro-2-cyclopropylideneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 2-chloro-(1-methanesulfonyloxy-cyclopropyl)acetate (832142-16-2) → methyl 2-chloro-2-cyclopropylideneacetate (82979-45-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 8h;

DOI:10.1002/adsc.200404025

Reference yield: 94.0%

trimethyl 2-chloro-2-cyclopropylidenorthoacetate (82979-34-8) → methyl 2-chloro-2-cyclopropylideneacetate (82979-45-1)

Guidance literature:

With hydrogen cation; In water; Ambient temperature;

Reference yield:

1-(2,2-dimethoxyethyl)cyclopropan-1-ol (832142-15-1) → methyl 2-chloro-2-cyclopropylideneacetate (82979-45-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridine / CH₂Cl₂ / 18 h / 20 °C

2.1: aq. HCl / tetrahydrofuran / 0.5 h / 0 °C

3.1: 14.6 g / aq. H₂O₂ / tetrahydrofuran / 8 h / 60 °C

4.1: SOCl₂ / 1,2-dichloro-ethane / 1 h / Heating

4.2: NCS; aq. HCl / 1,2-dichloro-ethane / 12 h / 90 °C

4.3: 93 percent / 1,2-dichloro-ethane / 1 h / 20 °C

5.1: 99 percent / Et₃N / CH₂Cl₂ / 8 h / 0 °C

With pyridine; hydrogenchloride; thionyl chloride; dihydrogen peroxide; triethylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1002/adsc.200404025

upstream raw materials:

trimethyl 2-chloro-2-cyclopropylidenorthoacetate

methyl 2-chloro-(1-methanesulfonyloxy-cyclopropyl)acetate

1-(2,2-dimethoxyethyl)cyclopropan-1-ol

1-(2,2-diethoxyethyl)cyclopropane-1-ol

Downstream raw materials:

Methyl 2-<1-(diphenylmethylene)aminocyclopropyl>-2-chloroacetate

methyl 2-chloro-2-<2'-(2-phenyl-2'-oxoethyl)cyclopropyl>acetate

methyl 2'-benzyloxy-6'-oxospiro2,7>octane>-1'-carboxylate

methyl 2-phenyl-5-(2'-chloroethyl)-5-(4''-nitrophenyl)-pyrrole-3-carboxylate