2-Pyrrolidinone, 1-[(2-bromophenyl)sulfonyl]-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]meth yl]-, (5S)-

Base Information

Chemical Name:2-Pyrrolidinone, 1-[(2-bromophenyl)sulfonyl]-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]meth yl]-, (5S)-
CAS No.:830319-82-9
Molecular Formula:C27H30BrNO4SSi
Molecular Weight:572.595
Hs Code.:

Synonyms:(S)-1-(2-Bromo-benzenesulfonyl)-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-2-one;

Suppliers and Price of 2-Pyrrolidinone, 1-[(2-bromophenyl)sulfonyl]-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]meth yl]-, (5S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Pyrrolidinone, 1-[(2-bromophenyl)sulfonyl]-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]meth yl]-, (5S)-

Chemical Property:

PSA：72.06000
LogP:5.72410

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Pyrrolidinone, 1-[(2-bromophenyl)sulfonyl]-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]meth yl]-, (5S)-

There total 3 articles about 2-Pyrrolidinone, 1-[(2-bromophenyl)sulfonyl]-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]meth yl]-, (5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2905-25-1
o-bromobenzenesulfonyl chloride

: 132974-83-5
(5S)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]pyrrolidin-2-one

: 830319-82-9
1-(2-bromobenzenesulfonyl)-5S-(tert-butyldiphenylsilanyloxymethyl)pyrrolidin-2-one

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 1h;
DOI:10.1021/ol0480123

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 830319-82-9
1-(2-bromobenzenesulfonyl)-5S-(tert-butyldiphenylsilanyloxymethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / triethylamine / CH₂Cl₂ / 120 h / 20 °C

2: 74 percent / n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol0480123

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 830319-82-9
1-(2-bromobenzenesulfonyl)-5S-(tert-butyldiphenylsilanyloxymethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / triethylamine / CH₂Cl₂ / 120 h / 20 °C

2: 74 percent / n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol0480123